QRFPR
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Official Full Name
pyroglutamylated RFamide peptide receptor -
Overview
Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene. -
Synonyms
QRFPR;pyroglutamylated RFamide peptide receptor;G protein coupled receptor 103 , GPR103;QRFP receptor;G protein-coupled receptor 103;G-protein coupled receptor 103;orexigenic neuropeptide QRFP receptor;AQ27;GPR103;SP9155;MGC149217
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- His&Fc&Avi
Involved Pathway
QRFPR involved in several pathways and played different roles in them. We selected most pathways QRFPR participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with QRFPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR ligand binding | EMR4,HCAR1-2,KEL,GPR31B,FZD10,CASR,SSTR3,OPN4A,GPR55,GCGA |
| GPCR downstream signaling | CCR7,CRH,CCR8,CXCL13,TAS2R3,CCR3,AMCF-II,GPR68,SST,RAMP1 |
| Signal Transduction | TAAR1,TLE2,CLIP3,NRP2B,NPS,OXGR1A.1,IRBP,RHOUA,DCLRE1B,GPRC6A |
| Gastrin-CREB signalling pathway via PKC and MAPK | RGS21,OXTRL,TRPC7,NPFF,EDNRAB,NMBA,ANXA1C,OPN4.1,UTS2,HCRT |
| Orexin and neuropeptides FF and QRFP bind to their respective receptors | NPFFR2,HCRT,QRFP,NPFF |
| Peptide ligand-binding receptors | XK,CCL27,PROKR1A,UTS2D,CXCL11.8,PNOCB,NMBB,RXFP2,INSL3,TRH |
| G alpha (q) signalling events | NMS,TRIO,RGS18,ANXA1C,TRPC3,FPR-RS4,LTB4R,PROK2,ABHD6B,EDNRB |
| Class A/1 (Rhodopsin-like receptors) | CHRM5,PENK,ADRA2B,RLN2,CGA,CXCR6,UTS2,KISS1,DRD2,POMCB |
Protein Function
QRFPR has several biochemical functions, for example, G-protein coupled receptor activity,neuropeptide Y receptor activity,peptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by QRFPR itself. We selected most functions QRFPR had, and list some proteins which have the same functions with QRFPR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| neuropeptide Y receptor activity | PROKR1,NPY2R,PRLHR,NPY1R,PRLHR2A,PRLH2R,PROKR2,NPY5R,NPY8BR,PRLHR2B |
| peptide binding | H2-Q10,CRIP1,GPR37L1,IDE,NPFFR1L3,FURIN,THOP1,CSNK1D,GPR22,CMA1 |
| G-protein coupled receptor activity | OLFR473,MRGPRF,FZD9,APLNRA,TACR1A,OLFR50,OR7D2,LPAR6A,VMN1R50,P2RY6 |
Interacting Protein
QRFPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with QRFPR here. Most of them are supplied by our site. Hope this information will be useful for your research of QRFPR.
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References
- Primeaux, SD; et al. QRFP in female rats: Effects on high fat food intake and hypothalamic gene expression across the estrous cycle. PEPTIDES 32:1270-1275(2011).
- Fukusumi, S; Fujii, R; et al. Recent advances in mammalian RFamide peptides: The discovery and functional analyses of PrRP, RFRPs and QRFP. PEPTIDES 27:1073-1086(2006).
- Fukusumi, S; Yoshida, H; et al. A new peptidic ligand and its receptor regulating adrenal function in rats. JOURNAL OF BIOLOGICAL CHEMISTRY 278:46387-46395(2003).
- Patel, SR; Murphy, KG; et al. Pyroglutamylated RFamide peptide 43 stimulates the hypothalamic-pituitary-gonadal axis via gonadotropin-releasing hormone in rats. ENDOCRINOLOGY 149:4747-4754(2008).
