Pilra
-
Official Full Name
paired immunoglobin-like type 2 receptor alpha -
Overview
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. -
Synonyms
PILRA;paired immunoglobin-like type 2 receptor alpha;paired immunoglobulin-like type 2 receptor alpha;FDF03;Cell surface receptor FDF03;Inhibitory receptor PILR-alpha;paired immunoglobulin-like receptor alpha;PILRA_HUMAN;paired immunoglobulin-like type 2 receptor alpha;PILRA;cell surface receptor FDF03;inhibitory receptor PILR-alpha;paired immunoglobulin-like receptor alpha;paired immunoglobin-like receptor alpha;OTTHUMP00000207544;OTTHUMP00000207543;OTTHUMP00000207542;OTTHUMP00000207541;inhibitory receptor PILRalpha
Recombinant Proteins
- Human
- Mouse
- Mammalian cells
- C-His
- HEK293
- Human Cell
- His
- Non
- Fc
- His&Fc&Avi
Involved Pathway
Pilra involved in several pathways and played different roles in them. We selected most pathways Pilra participated on our site, such as Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pilra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | ARNTL1B,CUL1,FADD,CUL1B,CASP3A,ARNTL,C3A.3,Ifna15,NXF2,HLA-DPA1 |
Protein Function
Pilra has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Pilra itself. We selected most functions Pilra had, and list some proteins which have the same functions with Pilra. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
Pilra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pilra here. Most of them are supplied by our site. Hope this information will be useful for your research of Pilra.
gB;PTPN6;DNPH1;rseA;SORBS1;vglh_hhv1f_protein
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesDendritic Cell ITIM/ITAM Immunoreceptors
Related Services
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References
