Phox2b
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Official Full Name
paired-like homeobox 2b -
Synonyms
PHOX2B;paired-like homeobox 2b;ENSMUSG00000012520;Dilp1;Pmx2b;NBPhox;5 C3.1;5 40.0 cM;paired mesoderm homeobox protein 2B;paired mesoderm homeobox protein 2B;GENA 269;dilated pupils 1;neuroblastoma Phox;PHOX2B homeodomain protein;paired mesoderm homeobox 2b
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PHOX2B-0410H | Recombinant Human PHOX2B protein, His-tagged | E.coli | Human | His | 63-314 aa | |
| PHOX2B-12752M | Recombinant Mouse PHOX2B Protein | Mammalian Cells | Mouse | His |
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| PHOX2B-668H | Recombinant Human PHOX2B | Mammalian Cells | Human | His |
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| PHOX2B-3216HCL | Recombinant Human PHOX2B 293 Cell Lysate | HEK293 | Human | Non |
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| PHOX2B-3851H | Recombinant Human PHOX2B Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| PHOX2B-3851H-B | Recombinant Human PHOX2B Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| PHOX2B-6710M | Recombinant Mouse PHOX2B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PHOX2B-6710M-B | Recombinant Mouse PHOX2B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
Phox2b involved in several pathways and played different roles in them. We selected most pathways Phox2b participated on our site, such as Neural Crest Differentiation,SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with Phox2b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SIDS Susceptibility Pathways | POU3F2,SCN3B,CREM,SNTA1,CTCF,MBD1,KCNJ8,MECP2,TAC1,IL1RN |
| Neural Crest Differentiation | LHX1,DLL3,PRTG,TXLNB,TCF4,HOXA1,MYB,GBX2,HEY2,SOX5 |
Protein Function
Phox2b has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Phox2b itself. We selected most functions Phox2b had, and list some proteins which have the same functions with Phox2b. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | GRHL1,CDX4,ZIC1,TFAP2B,NDN,ELF3,TTC6,MYC,HOXC11,EHF |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ZNF257,SPI1,GLI2,HIST2H3A,T,SIX1,HINFP,NOBOX,NACC2,IRF1 |
| RNA polymerase II regulatory region sequence-specific DNA binding | STAT4,ATF5A,RFX6,KAT2B,TRP53,MEF2C,CGGBP1,EGR1,ZNF584,GATA5 |
Interacting Protein
Phox2b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Phox2b here. Most of them are supplied by our site. Hope this information will be useful for your research of Phox2b.
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References
- Cheng, WWC; Tang, CSM; et al. Depletion of the IKBKAP ortholog in zebrafish leads to hirschsprung disease-like phenotype. WORLD JOURNAL OF GASTROENTEROLOGY 21:2040-2046(2015).
- Nonaka, D; Wang, BY; et al. A Study of Gata3 and Phox2b Expression in Tumors of the Autonomic Nervous System. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 37:1236-1241(2013).
