PYHIN1
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Official Full Name
pyrin and HIN domain family, member 1 -
Overview
The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
PYHIN1;pyrin and HIN domain family, member 1;pyrin and HIN domain-containing protein 1;IFIX;MGC23885;IFIX_HUMAN;Interferon-inducible protein X;OTTHUMP00000035198;OTTHUMP00000035199;OTTHUMP00000035200;OTTHUMP00000035201;RP11-520H16.1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PYHIN1-13754M | Recombinant Mouse PYHIN1 Protein | Mammalian Cell | Mouse | His |
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| PYHIN1-2643HCL | Recombinant Human PYHIN1 293 Cell Lysate | HEK293 | Human | Non |
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| PYHIN1-0629H | Recombinant Human PYHIN1 Protein (M1-P492), Flag tagged | E.coli | Human | Flag | M1-P492 |
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| PYHIN1-0630H | Recombinant Human PYHIN1 Protein (M1-P492), His/Strep tagged | E.coli | Human | His&Strep | M1-P492 |
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| PYHIN1-7318M | Recombinant Mouse PYHIN1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PYHIN1-7318M-B | Recombinant Mouse PYHIN1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PYHIN1 involved in several pathways and played different roles in them. We selected most pathways PYHIN1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PYHIN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PYHIN1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PYHIN1 itself. We selected most functions PYHIN1 had, and list some proteins which have the same functions with PYHIN1. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
PYHIN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PYHIN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PYHIN1.
isd;UL83;SUPT5H;AGRN;ZNF646;PPM1G;HTATSF1;SMARCA5;NBN;GPC4;RSL1D1;PHF14;PGK1;TFAP2A;LAMB1;PARP1;UCHL1;HIST1H1E
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