PVRL4
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Official Full Name
poliovirus receptor-related 4 -
Overview
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined. -
Synonyms
PVRL4;poliovirus receptor-related 4;poliovirus receptor-related protein 4;LNIR;nectin 4;PRR4;Ig superfamily receptor LNIR;Nectin-4;Processed poliovirus receptor-related protein 4;PVRL4_HUMAN;OTTHUMP00000029698;EDSS1
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- E.coli
- Mammalian cells
- Mammalian Cell
- HEK293
- HEK293F
- Yeast
- GST
- His
- Non
- Fc
- mFc
- His&Avi
- His&Fc&Avi
Involved Pathway
PVRL4 involved in several pathways and played different roles in them. We selected most pathways PVRL4 participated on our site, such as Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PVRL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adherens junction | FYN,EP300,PARD3,FYNB,EGFRA,IGF1R,RHOAC,TGFBR1B,WAS,RAC3A |
Protein Function
PVRL4 has several biochemical functions, for example, cell adhesion molecule binding,protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PVRL4 itself. We selected most functions PVRL4 had, and list some proteins which have the same functions with PVRL4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MC3R,SELL,FBXW7,CTTN,FAM82A2,TTC5,DVL2,PIK3CB,SP140,TBX5A |
| receptor binding | ADAM10,NPY,PICK1,CALCA,TNFSF4,FZD8,PCSK1N,IL29,A2M,ECH1 |
| protein homodimerization activity | IKBKG,CARD8,DMRT2,CAMK2G,RAB11FIP4,TGFB1,ABCB9,CHEK2,GRPEL2,PON3 |
| virus receptor activity | ITGB1,TFRC,SIVA1,SCARB1,SERPINB3,MOG,TYRO3,CD209A,IDE,CLEC4M |
| receptor activity | LRP1,CLEC4M,CD200R4,PAQR5B,V1RA8,CD46,DARC,ITGB1A,TNFRSF17,CADM2A |
| cell adhesion molecule binding | POSTNB,CAML,FGG,CADM2A,SELL,CADM1,NLGN3,NLGN1,PVRL3B,PVRL1A |
Interacting Protein
PVRL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PVRL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PVRL4.
PVRL1;H;TIGIT;PVRL2;MLLT4;Pick1
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References
- Melia, MM; Earle, JP; et al. Use of SLAM and PVRL4 and Identification of Pro-HB-EGF as Cell Entry Receptors for Wild Type Phocine Distemper Virus. PLOS ONE 9:-(2014).
- Abdullah, H; Brankin, B; et al. Wild-type Measles Virus Infection Upregulates Poliovirus Receptor-Related 4 and Causes Apoptosis in Brain Endothelial Cells by Induction of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 72:681-696(2013).
