PTRF
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Official Full Name
polymerase I and transcript release factor -
Overview
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3 end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009] -
Synonyms
PTRF;polymerase I and transcript release factor;CGL4;CAVIN;CAVIN1;FKSG13;cavin-1;TTF-I interacting peptide 12;RNA polymerase I and transcript release factor
Recombinant Proteins
- Chicken
- Mouse
- Human
- Mammalian Cell
- Mouse
- HEK293
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PTRF-1114C | Recombinant Chicken PTRF | Mammalian Cell | Chicken | His |
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| PTRF-13711M | Recombinant Mouse PTRF Protein | Mammalian Cell | Mouse | His |
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| PTRF-1442HCL | Recombinant Human PTRF cell lysate | Human | Non |
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| DMABT-H14716 | Mouse Anti-PTRF Monoclonal Antibody | Mouse | Human | Non |
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| PTRF-3163H | Recombinant Human PTRF Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| PTRF-7294M | Recombinant Mouse PTRF Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PTRF-7294M-B | Recombinant Mouse PTRF Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PTRF involved in several pathways and played different roles in them. We selected most pathways PTRF participated on our site, such as Gene Expression,RNA Polymerase I Transcription,RNA Polymerase I Transcription Termination, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTRF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | TFB2M,COX14,FAM36A,SEC61B,ELAVL1,ARHGEF38,ZNF606,ZNF253,POLR3G,COX6B1 |
| RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription | ZNF143B,NFIC,PTRFB,MBD3,ZNF143A,GTF3A,BRF1B,CRCP,SNAPC2,CHD4 |
| RNA Polymerase I Transcription | MBD3A,UBTF,CD3EAP,CBX3A,RRN3,CBX3,MTA2,GATAD2B,TAF1B,GATAD2AB |
| RNA Polymerase I Transcription Termination | PTRFB,UBTF |
Protein Function
PTRF has several biochemical functions, for example, poly(A) RNA binding,protein binding,rRNA primary transcript binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTRF itself. We selected most functions PTRF had, and list some proteins which have the same functions with PTRF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | KCTD12,ZNF346,STRAP,HIST1H4B,YARS2,RPL5A,REXO4,RPL19,UBFD1,TOP3B |
| protein binding | KPNA1,KCNE3,CBR4,HDC,GRID2IP,TTLL6,APBA3,C9orf43,RPL9,SEMA4C |
| rRNA primary transcript binding | NCL,IMP4,RPF1 |
Interacting Protein
PTRF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTRF here. Most of them are supplied by our site. Hope this information will be useful for your research of PTRF.
Incenp;midostaurin;ssrna_ug;Flot1;ATP6AP2;MYC;PTPN1;RAB5A;Rab5c;Bmpr1a;RAB5C;RAB7A;RAB2A;CKAP5;DBN1
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