PTPRT
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Official Full Name
protein tyrosine phosphatase, receptor type, T -
Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. -
Synonyms
PTPRT;protein tyrosine phosphatase, receptor type, T;receptor-type tyrosine-protein phosphatase T;KIAA0283;RPTPrho;R-PTP-T;RPTP-rho;receptor protein tyrosine phosphatase;receptor-type tyrosine-protein phosphatase rho
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Involved Pathway
PTPRT involved in several pathways and played different roles in them. We selected most pathways PTPRT participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
PTPRT has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRT itself. We selected most functions PTPRT had, and list some proteins which have the same functions with PTPRT. You can find most of the proteins on our site.
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Interacting Protein
PTPRT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRT here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRT.
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References
- Mohan, VK; Ganesan, N; et al. Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis. JOURNAL OF GENETICS 93:597-605(2014).
- Gianchecchi, E; Crino, A; et al. Altered B Cell Homeostasis and Toll-Like Receptor 9-Driven Response in Type 1 Diabetes Carriers of the C1858T PTPN22 Allelic Variant: Implications in the Disease Pathogenesis. PLOS ONE 9:-(2014).
