PTPRE
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Official Full Name
protein tyrosine phosphatase, receptor type, E -
Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. -
Synonyms
PTPRE;protein tyrosine phosphatase, receptor type, E;receptor-type tyrosine-protein phosphatase epsilon;PTPE;DKFZp313F1310;FLJ57799;FLJ58245;HPTPE;Protein tyrosine phosphatase epsilon;Protein tyrosine phosphatase receptor type E;Protein tyrosine phosphatase receptor type epsilon;Protein tyrosine phosphatase receptor type epsilon polypeptide;Protein-tyrosine phosphatase epsilon;PTPRE_HUMAN;R PTP Epsilon;R-PTP-epsilon;protein tyrosine phosphatase, receptor type, epsilon polypeptide
Recombinant Proteins
- Human
- Mouse
- Rat
- Mus musculus
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- E.coli expression system
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PTPRE involved in several pathways and played different roles in them. We selected most pathways PTPRE participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PTPRE has several biochemical functions, for example, protein binding,protein homodimerization activity,transmembrane receptor protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRE itself. We selected most functions PTPRE had, and list some proteins which have the same functions with PTPRE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SILV,TXNDC11,ZBP1,FERD3L,PAGE2,ZNF460,NPBWR1,SYCE1,LAT2,CAV3 |
| transmembrane receptor protein tyrosine phosphatase activity | PTPRB,PTPRA,PTPN6,PTPRN2,EVLA,PTPRUB,PTPRS,PTPRO,PTPRM,PTPRF |
| protein homodimerization activity | NPR3,PVRL4,APOBEC3G,SLC14A2,MAP3K13,TERF2,KCNE2,Anks6,PON1,DMRTC2 |
Interacting Protein
PTPRE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRE here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRE.
PDGFRB;FYN;Yes1
Resources
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References
- Mohan, VK; Ganesan, N; et al. Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis. JOURNAL OF GENETICS 93:597-605(2014).
- Vlam, L; Cats, EA; et al. Multifocal motor neuropathy is not associated with genetic variation in PTPN22, BANK1, Blk, FCGR2B, CD1A/E, and TAG-1 genes. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 16:175-179(2011).
