PTGIS
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Official Full Name
prostaglandin I2 (prostacyclin) synthase -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are;monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and;other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence;similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of;prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An;imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial;infarction, stroke, and atherosclerosis. -
Synonyms
PTGIS;prostaglandin I2 (prostacyclin) synthase;prostacyclin synthase;Cyp8;Pgis;Cyp8a1
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Mus musculus
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- E.coli expression system
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
PTGIS involved in several pathways and played different roles in them. We selected most pathways PTGIS participated on our site, such as Arachidonic acid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGIS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | GPX1,CYP4T8,CYP2C70,PLA2G4AA,ALOX8,PLA2G4C,CYP1A1,ALOX12,PLA2G16,CYP2AD6 |
| Metabolic pathways | COX7B,ACSL4,BAAT,ALG1,CMPK2,B4GALT2,INPP5B,BDH1,POLD4,PIP5K1AB |
Protein Function
PTGIS has several biochemical functions, for example, heme binding,iron ion binding,monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGIS itself. We selected most functions PTGIS had, and list some proteins which have the same functions with PTGIS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SPSB3,CD81,CHD4,CCT5,RGS3,MTX2,PCDHA4,LRRC47,ZNF576,NIF3L1 |
| iron ion binding | TMLHE,MFI2,TPH1,CYP1C1,HBE,CYP19A1A,CYP2AD6,SCD,IRGM1,CYP4Z1 |
| monooxygenase activity | FAM84B,CYP3A5,TH2,CYP2AA7,CYP2AA3,CYP2C50,CYP2P7,CYP3A43,CYP2X10.2,CYP2AA9 |
| heme binding | CYP3C1,CYP2AA3,CYP2D9,CBS,HBA2,CYP21A2,HBD,EPX,CYGB2,CYP27B1 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP4A10,PLOD1A,CYP2C50,CYP2K18,CYP46A1.3,CYP1D1,CYP2AA9,CYP2C70,CYP2AA12,CYP2K19 |
Interacting Protein
PTGIS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGIS here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGIS.
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