PTGDR2
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Official Full Name
prostaglandin D2 receptor 2 -
Overview
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3 UTR of this gene have been associated with asthma susceptibility. -
Synonyms
PTGDR2;prostaglandin D2 receptor 2;G protein coupled receptor 44 , GPR44;putative G-protein coupled receptor 44;CD294;chemoattractant receptor homologous molecule expressed on T helper type 2 cells;CRTH2;DP2;CD294 antigen;Chemoattractant receptor homologous molecule expressed on Th2 cells;Chemoattractant receptor-homologous molecule expressed on Th2 cells;CRTH 2;DL1R;G Protein Coupled Receptor 44;GPR 44;Gpr44;GPR44_HUMAN;Putative G protein coupled receptor 44;G protein-coupled receptor 44
Recombinant Proteins
- Rat
- Human
- Mammalian Cells
- HEK293
- Protein Conjugation
- E.coli
- His
- His&Flag
- His&Fc&Avi
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PTGDR2-4803R | Recombinant Rat PTGDR2 Protein | Mammalian Cells | Rat | His |
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| PTGDR2-1135HFL | Recombinant Human PTGDR2 protein, His&Flag-tagged | HEK293 | Human | His&Flag | 1-395 aa |
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| PTGDR2-2812H | Recombinant Human PTGDR2 Protein, His-tagged, OVA Conjugated | Protein Conjugation | Human | His | Asp329-Ala348 |
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| PTGDR2-4462R | Recombinant Rat PTGDR2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PTGDR2-4462R-B | Recombinant Rat PTGDR2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PTGDR2-932H | Recombinant Human PTGDR2 Full Length Transmembrane protein(Nanodisc) | HEK293 | Human | Non | Full L. |
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| RFL19244HF | Recombinant Full Length Human Prostaglandin D2 Receptor 2(Ptgdr2) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length (1-395) |
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| RFL26992RF | Recombinant Full Length Rat Prostaglandin D2 Receptor 2(Ptgdr2) Protein, His-Tagged | E.coli | Rat | His | Full L. Full Length (1-403) |
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Involved Pathway
PTGDR2 involved in several pathways and played different roles in them. We selected most pathways PTGDR2 participated on our site, such as Class A/1 (Rhodopsin-like receptors),Eicosanoid ligand-binding receptors,G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGDR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR ligand binding | TAC1,EMR4,TAS2R3,GPR18,GNB5B,QRFPR,PYY,PTHLH,SSTR4,OPN1LW2 |
| GPCRs, Class A Rhodopsin-like | GPR77,DRD4,GPR12,SSTR1,GPR17,GPR3,SSTR3,LTB4R,GPR18,HRH3 |
| Eicosanoid ligand-binding receptors | GPR17,CYSLTR1,LTB4R,OXER1 |
| Signal Transduction | WNT8-2,NPFF,RARG,PTHRP2,DACT1,RHOT1A,INTU,SCUBE2,LRIG1,GPR4 |
| Class A/1 (Rhodopsin-like receptors) | NPB,ADRA1B,UTS2,OPN4.1,CYSLTR1,SST1.1,OPN5,GPR4,OPN1MW2,FPR-RS4 |
| G alpha (i) signalling events | RGS18,CCR3,LPAR2A,GPR17,LPAR1,SSTR5,DRD3,CNR1,PMCH,LPAR5A |
| GPCR downstream signaling | ANXA1A,ADORA3,RGS6,TRPC3,EDNRAB,RGS18,ABHD12,DRD3,ARHGEF17,GAL |
Protein Function
PTGDR2 has several biochemical functions, for example, G-protein coupled receptor activity,neuropeptide binding,prostaglandin D receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGDR2 itself. We selected most functions PTGDR2 had, and list some proteins which have the same functions with PTGDR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| prostaglandin J receptor activity | PTGDR |
| neuropeptide binding | SSTR1,OPRK1,OPRM1,GPR149,OPRL1,NPY8BR,SSTR4,SSTR2,OPRD1B,MC4R |
| prostaglandin F receptor activity | PTGER1C,PTGFR |
| prostaglandin D receptor activity | PTGDR |
| G-protein coupled receptor activity | HTR1AA,OLFR470,GPR1,ZFPM2B,OLFR154,NTSR2,OPN4XA,GPR113,GHRHRA,OLFR497 |
Interacting Protein
PTGDR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGDR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGDR2.
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