PTF1A

  • Official Full Name

    pancreas specific transcription factor, 1a

  • Overview

    This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.

  • Synonyms

    PTF1A;pancreas specific transcription factor, 1a;pancreas transcription factor 1 subunit alpha;bHLHa29;PTF1 p48;class II bHLH protein PTF1A;bHLH transcription factor p48;class A basic helix-loop-helix protein 29;pancreas-specific transcription fac

Recombinant Proteins

  • Zebrafish
  • Rat
  • Human
  • Mammalian Cell
  • E.coli
  • HEK293
  • His
  • His&GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PTF1A-11836Z Recombinant Zebrafish PTF1A Mammalian Cell Zebrafish His
PTF1A-4801R Recombinant Rat PTF1A Protein Mammalian Cell Rat His
PTF1A-8038H Recombinant Human PTF1A protein, His-tagged E.coli Human His Gln177~Ser328
PTF1A-8039H Recombinant Human PTF1A protein, His & GST-tagged E.coli Human His&GST Gln177~Ser328
PTF1A-2638H Recombinant Human PTF1A Protein, His-tagged E.coli Human His Ala48-Pro115
PTF1A-4460R Recombinant Rat PTF1A Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
PTF1A-4460R-B Recombinant Rat PTF1A Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    PTF1A involved in several pathways and played different roles in them. We selected most pathways PTF1A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    PTF1A has several biochemical functions, for example, DNA binding,protein dimerization activity,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTF1A itself. We selected most functions PTF1A had, and list some proteins which have the same functions with PTF1A. You can find most of the proteins on our site.

    Function Related Protein
    sequence-specific DNA binding FOXG1C,NOTCH1,HOXD4A,POU2F2,ZNF148,HOXA1A,NKX6.1,RXRGA,TFAP4,HOXB8A
    DNA binding TWIST2,CDK5R2,PREB,ZNF496,TFDP3,HER12,HEMK1,CHTF8,HER9,TFAP2B
    protein dimerization activity AHR1A,NEUROD6B,PPP3CA,ANO7,PEF1,DNM1,NEUROD6,MITF,AIFM1,MYCA
    transcription factor activity, sequence-specific DNA binding TBR1,ZFP184,FOXC2,EVX1,PIP4K2AA,ZHX2,VAX2,SOX11B,MEOX2,HOXA5

    Interacting Protein

    PTF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PTF1A.

    Resources

    Research Area

    Pancreatic Endoderm Cell Markers
    Pancreatic Progenitor Cell Transcription Factors
    Cancer Stem Cell Transcription Factors
    Hepatic and Pancreatic Progenitor Cell Transcription Factors
    Endodermal Lineage Markers

    References

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