PTCH2
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Official Full Name
patched 2 -
Overview
This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described. -
Synonyms
PTC2;PTCH2;Patched Tumor Suppressor 2;protein patched homolog 2;patched homolog 2;OTTHUMP00000010158
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PTCH2-13625M | Recombinant Mouse PTCH2 Protein | Mammalian Cell | Mouse | His |
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| PTCH2-8624Z | Recombinant Zebrafish PTCH2 | Mammalian Cell | Zebrafish | His |
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| PTCH2-1097H | Recombinant Human PTCH2 protein, His&Myc-tagged | E.coli | Human | His&Myc | 79-392aa |
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| PTCH2-7244M | Recombinant Mouse PTCH2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PTCH2-7244M-B | Recombinant Mouse PTCH2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PTCH2 involved in several pathways and played different roles in them. We selected most pathways PTCH2 participated on our site, such as Hedgehog signaling pathway,Pathways in cancer,Basal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTCH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Basal cell carcinoma | AXIN2,WNT2,FZD9,APC2,PTCH1,TCF7,DVL2,GLI3,WNT5A,APC |
| Hedgehog signaling pathway | PRKACBB,LRP2A,WNT7AA,SMO,Shh,CSNK1G2,WNT7A,ZIC2A,BTRC,WNT2BB |
| Pathways in cancer | TGFB3,MMP2,FZD1,GNG4,NKX3-1,VEGFA,CCNE1,NFKB2,GNG11,FLT3 |
Protein Function
PTCH2 has several biochemical functions, for example, hedgehog family protein binding,hedgehog receptor activity,smoothened binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTCH2 itself. We selected most functions PTCH2 had, and list some proteins which have the same functions with PTCH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hedgehog receptor activity | PTCHD1,PTCH1,PTCHD4,B9D1,PTCHD3,NPC1,DISP1 |
| smoothened binding | PTCH1,BBS1 |
| hedgehog family protein binding | PTCH1,HHIP |
Interacting Protein
PTCH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTCH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTCH2.
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