PSPC1
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Official Full Name
paraspeckle component 1 -
Overview
This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. -
Synonyms
PSPC1;paraspeckle component 1;FLJ10955;PSP1;paraspeckle protein 1;FLJ33554;DKFZp566B1447
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
PSPC1 involved in several pathways and played different roles in them. We selected most pathways PSPC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PSPC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PSPC1 has several biochemical functions, for example, core promoter binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSPC1 itself. We selected most functions PSPC1 had, and list some proteins which have the same functions with PSPC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | SURF6,G3BP2,HIST1H4C,CPEB2,ROCK2,RPS5,EXOSC10,CHST13,NHP2,FYTTD1 |
| nucleotide binding | POLDIP3,RBM18,WEE2,BMPR1BA,PTBP2,TTLL11,SSB,NXF1,MTIF2,SRSF1A |
| transcription regulatory region sequence-specific DNA binding | NR5A1B,SOX2,SIN3A,BTBD8,HIF1AL,NR5A1A,NFE2L1,NFE2,CRY2,CREB3L3 |
| protein binding | RPL4,ZNF580,TNFAIP8,FANCI,CD6,CNTNAP1,KRT8,TTI1,GRIN3A,TRAPPC3 |
| core promoter binding | PYDC3,NPAS2,INSM1A,HDAC2,AGO1,MYOD1,IFI203,KDM3A,SFPQ,HDAC1 |
Interacting Protein
PSPC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSPC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSPC1.
NONO;140258;NONO;KRT31
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References
- Gremlich, S; Damnon, F; et al. The long non-coding RNA NEAT1 is increased in IUGR placentas, leading to potential new hypotheses of IUGR origin/development. PLACENTA 35:44-49(2014).
- Naganuma, T; Hirose, T; et al. Paraspeckle formation during the biogenesis of long non-coding RNAs. RNA BIOLOGY 10:456-461(2013).
