PSMC6
-
Official Full Name
proteasome (prosome, macropain) 26S subunit, ATPase, 6 -
Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. -
Synonyms
PSMC6;proteasome (prosome, macropain) 26S subunit, ATPase, 6;26S protease regulatory subunit 10B;p42;26S protease regulatory subunit S10B;26S proteasome AAA-ATPase subunit RPT4;CADP44;P44;Proteasome 26S subunit ATPase 6;Proteasome subunit p42;PRS10_HUMAN;Rpt4;SUG2;OTTHUMP00000179002;OTTHUMP00000245246;conserved ATPase domain protein 44
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PSMC6 involved in several pathways and played different roles in them. We selected most pathways PSMC6 participated on our site, such as Proteasome,Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMB9B,PSMD11A,PSME4,PSME2,PSMA6A,SHFM1,PSMD12,PSMA4,PSME4B,PSMA7 |
| Epstein-Barr virus infection | MAP2K6,POLR2J3,MAP3K7,POLR2H,BCL2,MAPK11,NFKBIE,PSMD2,HLA-DQA2,TBP |
Protein Function
PSMC6 has several biochemical functions, for example, ATP binding,ATPase activity,TBP-class protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMC6 itself. We selected most functions PSMC6 had, and list some proteins which have the same functions with PSMC6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding, bridging | FGA,BFAR,AMFR,NEFL,TRIM6,CRADD,VPS18,TCAP,FBXW7,PPP4R2 |
| ATP binding | NUAK2,ACTC1,KLHL8,BBS10,PTK2AA,ABCG2B,TOR2A,NLRP7,ADCY1,CDC34 |
| proteasome-activating ATPase activity | PSMC4,PSMC3,PSMC1A,PSMC1,PSMC1B,PSMC5,PSMC2 |
| ATPase activity | HSPA5,PSMC4,ABCC1,KIF12,ABCF3,MYO19,ABCG3,ABCA4A,VPS4A,ABCG4B |
| TBP-class protein binding | PSMC1,TAF1,DR1,CAND1,BRF1,THRA,PSMC5,GTF2A2,PSMC1B,TAF1L |
| protein binding | NRIP1,TMEM106B,TCTN2,CCDC130,CD19,DCUN1D1,RPS6KC1,PDZD7,DBNDD2,ZNF32 |
Interacting Protein
PSMC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMC6.
PSMD9;PSMC3;PSMC5
Resources
Related Services
Related Products
References
- Sjakste, T; Paramonova, N; et al. Juvenile Idiopathic Arthritis Subtype- and Sex-specific Associations with Genetic Variants in the PSMA6/PSMC6/PSMA3 Gene Cluster. PEDIATRICS AND NEONATOLOGY 55:393-403(2014).
- Kim, HY; Byun, MJ; et al. A replication study of genome-wide CNV association for hepatic biomarkers identifies nine genes associated with liver function. BMB REPORTS 44:578-583(2011).
