PSMC2

  • Official Full Name

    proteasome (prosome, macropain) 26S subunit, ATPase, 2

  • Overview

    The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

  • Synonyms

    PSMC2;proteasome (prosome, macropain) 26S subunit, ATPase, 2;26S protease regulatory subunit 7;mammalian suppressor of sgv 1 of yeast;MSS1;Nbla10058;protease 26S subunit 7;proteasome 26S subunit;ATPase;2;putative protein product of Nbla10058;S7;26S protease complex;mammalian suppressor of sgv-1 of yeast;proteasome 26S ATPase subunit 2;Proteasome 26S subunit ATPase2;proteasome 26S subunit ATPase 2;Protein MSS1;OTTHUMP00000211710;OTTHUMP00000211711;OTTHUMP00000211712;proteasome 26S subunit, ATPase, 2;26S proteasome AAA-ATPase subunit RPT

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Rat
  • E.coli
  • Mammalian Cell
  • HEK293
  • His
  • T7
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PSMC2-2023H Recombinant Human PSMC2, His-tagged E.coli Human His 84-433aa
PSMC2-419H Recombinant Human PSMC2 Protein, His-tagged E.coli Human His Met1~Asn433
PSMC2-11201Z Recombinant Zebrafish PSMC2 Mammalian Cell Zebrafish His
PSMC2-1373C Recombinant Chicken PSMC2 Mammalian Cell Chicken His
PSMC2-3023H Recombinant Human Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2, T7-tagged E.coli Human T7
PSMC2-4779R Recombinant Rat PSMC2 Protein Mammalian Cell Rat His
PSMC2-2764HCL Recombinant Human PSMC2 293 Cell Lysate HEK293 Human Non
PSMC2-4438R Recombinant Rat PSMC2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
PSMC2-4438R-B Recombinant Rat PSMC2 Protein Pre-coupled Magnetic Beads HEK293 Rat
PSMC2-6040H Recombinant Human PSMC2 Protein (Met1-Asn433), His tagged E.coli Human His Met1-Asn433

    Involved Pathway

    PSMC2 involved in several pathways and played different roles in them. We selected most pathways PSMC2 participated on our site, such as Proteasome,Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Epstein-Barr virus infection POLR3B,PRKACG,NFKB2,SND1,IFNG,EIF2AK1,TP53,IKBKG,ENTPD3,RELA
    Proteasome PSMC1B,PSMC6,IFNG,PSMD6,PSMB9B,POMP,PSMA1,PSMB11,PSMD2,PSMB1

    Protein Function

    PSMC2 has several biochemical functions, for example, ATP binding,ATPase activity,TBP-class protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMC2 itself. We selected most functions PSMC2 had, and list some proteins which have the same functions with PSMC2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ULK1A,GRK1A,MAT2AA,CAMK1G,YARS2,CSF1RA,GSK3A,DDX28,TOR1,TOR2A
    protein binding RAD9,KCP,KPNA4,FAM118A,HDAC5,KAT2B,CIAO1,ZMYM4,STAT4,RPS25
    ATPase activity KIF2B,KIF27,ABCG4B,MYO19,ABCG2D,ABCG2A,MLH3,ERCC3,ABCF2,KIF15
    TBP-class protein binding PSMC5,DR1,BRF1B,BRF1,PSMC4,PSMC1,PSMC1A,GTF2A1,TAF1B,EFCAB11
    proteasome-activating ATPase activity PSMC4,PSMC1B,PSMC1A,PSMC1,PSMC3,PSMC6,PSMC5

    Interacting Protein

    PSMC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMC2.

    PSMD5;PSMC5

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