PRPS2

  • Official Full Name

    phosphoribosyl pyrophosphate synthetase 2
  • Overview

    This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants.
  • Synonyms

    PRPS2;phosphoribosyl pyrophosphate synthetase 2;ribose-phosphate pyrophosphokinase 2;PRS II;ribose phosphate diphosphokinase 2;EC 2.7.6.1;Phosphoribosyl pyrophosphate synthetase II;PPRibP;Ribose phosphate pyrophosphokinase II;PRS-II;PPRibP synthetase;OTTHUMP00000022921;OTTHUMP00000214964;OTTHUMP00000214965;ribose-phosphate diphosphokinase 2;phosphoribosyl pyrophosphate synthase II;PRSII

Recombinant Proteins

  • Human
  • Chicken
  • Rat
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • His&T7
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PRPS2-3750H Recombinant Human PRPS2 protein, GST-tagged E.coli Human GST 143-273 aa
PRPS2-1411C Recombinant Chicken PRPS2 Mammalian Cells Chicken His
PRPS2-181H Recombinant Human PRPS2, His-tagged HEK293 Human His
PRPS2-189H Recombinant Human PRPS2 protein, T7/His-tagged E.coli Human His&T7 319 a.a.
PRPS2-374H Recombinant Human PRPS2 protein, His-tagged E.coli Human His Met1-Leu318
PRPS2-4724R Recombinant Rat PRPS2 Protein Mammalian Cells Rat His
PRPS2-90H Recombinant Human PRPS2, His-tagged E.coli Human His
PRPS2-505HCL Recombinant Human PRPS2 lysate HEK293 Human Non
PRPS2-3030H Recombinant Human PRPS2 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
PRPS2-4383R Recombinant Rat PRPS2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
PRPS2-4383R-B Recombinant Rat PRPS2 Protein Pre-coupled Magnetic Beads HEK293 Rat
Prps2-479M Recombinant Mouse Prps2 Protein, MYC/DDK-tagged HEK293 Mouse Myc&DDK
PRPS2-6013H Recombinant Human PRPS2 Protein (Pro2-Leu318), C-His tagged Mammalian Cells Human His Pro2-Leu318

    Involved Pathway

    PRPS2 involved in several pathways and played different roles in them. We selected most pathways PRPS2 participated on our site, such as Pentose phosphate pathway,Purine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose phosphate pathway TKTL1,RGN,RBKS,GPIB,FBP2,PFKMB,GPI1,TALDO1,FBP1B,PGM1
    Biosynthesis of amino acids PFKL,BCAT1,GPT2,PGAM1,PKMB,ALDOCB,PRPS1A,ACY1,GOT2,PSAT1
    Metabolic pathways HYAL4,NT5C1B,R05D11.9,GALNTL4,GBGT1L4,NME5,PAICS,PCYT2,PET112L,C1GALT1A
    Carbon metabolism GLUD2,HADHAB,GM5506,G6PDX,SDHDA,MDH1AA,TALDO1,RGN,PFKMA,PFKL
    Purine metabolism IMPDH1,POLR2E,GUK1,POLR3B,GUCY1A3,CECR1A,TWISTNB,POLD2,NPR1,POLR3GL

    Protein Function

    PRPS2 has several biochemical functions, for example, ADP binding,AMP binding,ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPS2 itself. We selected most functions PRPS2 had, and list some proteins which have the same functions with PRPS2. You can find most of the proteins on our site.

    Function Related Protein
    GDP binding RAB4A,GNAI1,RAB8B,RAB14,GEM,RAB18,PIGC,RAB12,RAB22A,SRP54
    identical protein binding ZBTB16,WRNIP1,YWHAZ,FGFR1,TPRGL,SEPHS1,TLR3,DDX58,SORD,CLPP
    kinase activity CSNK1DB,SMG1,CAMK2G1,PKN2,LIMK1A,INSRA,HMGXB3,MAP2K2A,MTOR,UCK2B
    ATP binding FBXO18,MYLK,ACTG1,DDX39,DSTYK,TEK,GAK,ATPBD4,TXK,PTK2AA
    carbohydrate binding CLEC4F,MGAT2,PYGM,LGALS7B,OS9,FCN1,REG3A,LPHN1,GALNT4,GALNT5
    AMP binding APRT,PRKAG2,ACSS2,CYB5R3,ACSS1,PYGL,PRPS1,PRKAG1,PYGM,FBP1
    magnesium ion binding STK3,PRPSAP1,COMT,PRPS1L1,S100P,HPGDS,PPM1B,FARSB,ATP9B,DXO
    ADP binding MYH10,ADCK3,PRKAG1,PRPS1,TAP1,VCP,PKM,ERN1,GCLC,LONP1
    protein binding MS4A1,NTRK3,USP1,ZNF581,NOP10,PRCP,ROPN1L,FOXK2,CALCOCO1,GRIK5

    Interacting Protein

    PRPS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPS2.

    PRPS1;PRPSAP1;NOTCH2NL;WDYHV1

    Resources

    References

    • Cunningham, JT; Moreno, MV; et al. Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer. CELL 157:1088-1103(2014).
    • Fridman, A; Saha, A; et al. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. BIOCHEMICAL JOURNAL 454:91-99(2013).

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