PRPF18
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Official Full Name
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae) -
Overview
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. -
Synonyms
PRPF18;PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae);PRP18 pre mRNA processing factor 18 homolog (yeast);pre-mRNA-splicing factor 18;hPrp18;FLJ10210;Pre mRNA splicing factor 18;PRP18;PRP18 homolog;PRP18 pre mRNA processing factor 18 homolog (PRPF18);PRP18 pre mRNA processing factor 18 homolog (S. cerevisiae);PRP18_HUMAN;PRP18 pre-mRNA processing factor 18 homolog(PRPF18)
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Rat
- Human
- Mouse
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PRPF18-3622R | Recombinant Rhesus monkey PRPF18 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| PRPF18-421Z | Recombinant Zebrafish PRPF18 | Mammalian Cell | Zebrafish | His |
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| PRPF18-4717R | Recombinant Rat PRPF18 Protein | Mammalian Cell | Rat | His |
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| PRPF18-2829HCL | Recombinant Human PRPF18 293 Cell Lysate | HEK293 | Human | Non |
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| PRPF18-2350H | Recombinant Human PRPF18 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| PRPF18-3440R | Recombinant Rhesus Macaque PRPF18 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PRPF18-3440R-B | Recombinant Rhesus Macaque PRPF18 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| PRPF18-4376R | Recombinant Rat PRPF18 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PRPF18-4376R-B | Recombinant Rat PRPF18 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Prpf18-5144M | Recombinant Mouse Prpf18 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
PRPF18 involved in several pathways and played different roles in them. We selected most pathways PRPF18 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPF18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | SF3B5,NCBP2,ISY1,AQR,SNRNP40,CWC15,CRNKL1,ISY1-RAB43,EIF4A3,HNRNPA1L2 |
Protein Function
PRPF18 has several biochemical functions, for example, contributes_to second spliceosomal transesterification activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPF18 itself. We selected most functions PRPF18 had, and list some proteins which have the same functions with PRPF18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to second spliceosomal transesterification activity | CDC40 |
Interacting Protein
PRPF18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPF18 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPF18.
sdhA;Nek2;YWHAZ;Ddb1
Resources
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References
- Zubovic, L; Baralle, M; et al. Mutually exclusive splicing regulates the Na-v 1.6 sodium channel function through a combinatorial mechanism that involves three distinct splicing regulatory elements and their ligands. NUCLEIC ACIDS RESEARCH 40:6255-6269(2012).
- Ezeokonkwo, C; Ghazy, MA; et al. Novel interactions at the essential N-terminus of poly(A) polymerase that could regulate poly(A) addition in Saccharomyces cerevisiae. FEBS LETTERS 586:1173-1178(2012).
