PROX1
-
Official Full Name
prospero homeobox 1 -
Overview
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] -
Synonyms
PROX1;prospero homeobox 1;prospero homeobox protein 1;prospero-related homeobox 1;homeobox prospero-like protein PROX1
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
PROX1 involved in several pathways and played different roles in them. We selected most pathways PROX1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PROX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PROX1 has several biochemical functions, for example, DBD domain binding,DNA binding,LBD domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PROX1 itself. We selected most functions PROX1 had, and list some proteins which have the same functions with PROX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligand-dependent nuclear receptor binding | ISL1,C1D,PPARGC1A,MED1,SMARCE1,SRA1,TRIP4,NCOR1,JUND,ARID1A |
| DNA binding | ISL2,TAF9,SSH3,ZFP326,HIST2H3C,NFE2L1B,BSX,HELZ2,HDGF2,ZNF654 |
| transcription factor activity, sequence-specific DNA binding | CREBL2,PAX6,ZIK1,XBP1,HNF1B,HOXB8,CREB5,Ar,HOXB8A,ZSCAN4C |
| transcription regulatory region DNA binding | XRCC6,BASP1,SOX7,ARID5B,HHEX,RNF10,TBL1X,Ar,H2AFY2,ARID5A |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | JUN,RELA,GATA4,NFATC1,TFAP4,CEBPA,BHLHE40,NR1H4,SRF,GTF2IRD1 |
| protein binding | LAMP2,CHMP5,TAF6L,RAD51,CDK18,ABTB1,LPP,DNALI1,SNRPF,TTC33 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | GZF1,NFIL3,HHEX,HELT,PRDM5,SP3,GATA3,MYPOP,ZFP90,CUX2 |
| transcription corepressor activity | SKOR1A,CBX4,SIAH2,MNT,SSX5,JUNB,MSC,KCNIP3,TRIM28,NFKBIL2 |
| LBD domain binding | MED1,CITED1,CITED2 |
Interacting Protein
PROX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PROX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PROX1.
NR5A2;HNF4A;HNF1A;CTBP2;NR5A2;HDAC3;SUMO1
Resources
Research Area
Transcription Regulators in Endothelial CellsHepatic Progenitor Cell Transcription Factors
Cancer Stem Cell Transcription Factors
Hematopoietic Stem Cell Transcription Factors and Regulators
Hepatic and Pancreatic Progenitor Cell Transcription Factors
Neural Stem Cell Transcription Factors
Endodermal Lineage Markers
Related Services
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References
- Aspelund, A; Tammela, T; et al. The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. JOURNAL OF CLINICAL INVESTIGATION 124:3975-3986(2014).
- Wang, L; Gao, TW; et al. Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma. JOURNAL OF CUTANEOUS PATHOLOGY 41:447-450(2014).
