PRKAR2A
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Official Full Name
protein kinase, cAMP-dependent, regulatory, type II, alpha -
Overview
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008] -
Synonyms
PRKAR2A;protein kinase, cAMP-dependent, regulatory, type II, alpha;PKR2;PRKAR2;cAMP-dependent protein kinase type II-alpha regulatory subunit;protein kinase A, RII-alpha subunit;cAMP-dependent protein kinase regulatory subunit RII alpha
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- E. coli
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PRKAR2A-4675R | Recombinant Rat PRKAR2A Protein | Mammalian Cell | Rat | His |
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| PRKAR2A-81H | Recombinant Human PRKAR2A Protein, His-tagged | E.coli | Human | His | 1-404 a.a. |
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| PRKAR2A-2861HCL | Recombinant Human PRKAR2A 293 Cell Lysate | HEK293 | Human | Non |
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| PRKAR2A-4334R | Recombinant Rat PRKAR2A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PRKAR2A-4334R-B | Recombinant Rat PRKAR2A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Prkar2a-5116M | Recombinant Mouse Prkar2a Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| PRKAR2A-5258H | Recombinant Human PRKAR2A protein, His-tagged | E. coli | Human | His | 397 aa (including fusion tag) |
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Involved Pathway
PRKAR2A involved in several pathways and played different roles in them. We selected most pathways PRKAR2A participated on our site, such as Apoptosis,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAR2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin signaling pathway | PIK3R3,SHC1,HK3,MAP2K2,MAP2K2A,AKT1,INSB,MAPK8A,FOXO1B,PPP1CA |
| Apoptosis | TP53,HIST1H1C,IL3,CASP12,DFFB,CAPN1B,BNIP3LB,CASP10,E2F1,CASP3B |
Protein Function
PRKAR2A has several biochemical functions, for example, cAMP binding,cAMP-dependent protein kinase inhibitor activity,cAMP-dependent protein kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAR2A itself. We selected most functions PRKAR2A had, and list some proteins which have the same functions with PRKAR2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase A catalytic subunit binding | PKIA,GSK3B,PRKAR2B,GSK3A,CSK,PRKAR1B,SOX9,PJA2,RYR2,EZR |
| cAMP-dependent protein kinase inhibitor activity | PRKAR2B,PKIB,PRKAG2,PKIA,PRKAR1A,PKIG,PRKAR1B |
| cAMP-dependent protein kinase regulator activity | PRKAR2B,PRKAR2AA,PRKAR1A,CXCL10,PRKAR1AA,PRKAG2,PRKAR1AB,PRKAR1B,PRKAR2AB,PRKAG1 |
| protein binding | METTL9,HOXA5,EIF3H,CDC37,SMAD3,RINT1,ZBTB7B,CTCF,CYTH3,PLCE1 |
| cAMP binding | RAPGEF3,PRKAR2B,PDE3A,PDE4A,PDE11A,BVES,HCN2,CNGA2,PDE4D,POPDC2 |
| ubiquitin protein ligase binding | UBE2V1,UBE2N,CKB,STUB1,MYOD1,PPARGC1A,FANCL,TRIM28,NAE1,WASH1 |
Interacting Protein
PRKAR2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAR2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAR2A.
AKAP1;p03259-2;3',5'-cyclic amp;PRKACA;AKAP5;AKAP3;8-aha-camp
Resources
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References
- Han, YS; Arroyo, J; et al. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538:25-33(2013).
- Kronberg, F; Giacometti, R; et al. Characterization of the regulatory subunit of Yarrowia lipolytica cAMP-dependent protein kinase. Evidences of a monomeric protein. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 509:66-75(2011).
