PRICKLE1
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Official Full Name
prickle homolog 1 (Drosophila) -
Overview
This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. -
Synonyms
PRICKLE1;prickle homolog 1 (Drosophila);prickle like 1 (Drosophila);prickle-like protein 1;EPM1B;FLJ31937;FLJ31627;MGC138902;MGC138903;Prickle 1;Prickle like protein 1;Prickle-like 1;REST-Interacting LIM Domain Protein;REST/NRSF interacting LIM domain protein 1;RILP;REST/NRSF-interacting LIM domain protein 1;REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PRICKLE1-1943H | Recombinant Human PRICKLE1, GST-tagged | E.coli | Human | GST | 321-580aa | |
| PRICKLE1-13342M | Recombinant Mouse PRICKLE1 Protein | Mammalian Cells | Mouse | His |
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| PRICKLE1-2871HCL | Recombinant Human PRICKLE1 293 Cell Lysate | HEK293 | Human | Non |
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| PRICKLE1-7081M | Recombinant Mouse PRICKLE1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PRICKLE1-7081M-B | Recombinant Mouse PRICKLE1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PRICKLE1 involved in several pathways and played different roles in them. We selected most pathways PRICKLE1 participated on our site, such as Asymmetric localization of PCP proteins,Beta-catenin independent WNT signaling,PCP/CE pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRICKLE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Beta-catenin independent WNT signaling | DVL1,DVL2,ROR2,DVL3,ITPR2,MOV10,CTNNB2,CLTB,AGO2,RYK |
| Signaling by Wnt | SOX4B,WIF1,RBBP5,RYK,ZNRF3,PYGO2,RSPO3,CCDC88C,RSPO2,WNT8-2 |
| Wnt signaling pathway | TLE3A,SOST,PRKCG,PPP3R1B,SMAD4,CER1,CUL1,FZD9B,FOSL1,SIAH2L |
| Signal Transduction | EMR3,FGD2,RGS11,RGS1,APOA4B.1,OPN4.1,RNF43,RHOT1,CCBP2,NMB |
| Asymmetric localization of PCP proteins | PRICKLE1B,DVL2 |
| PCP/CE pathway | ROR1,ROR2,RYK,PRICKLE1B |
Protein Function
PRICKLE1 has several biochemical functions, for example, protein binding,transcription factor binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRICKLE1 itself. We selected most functions PRICKLE1 had, and list some proteins which have the same functions with PRICKLE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ADRM1,DPH1,HMGA2,PRPF19,SDC4,RABIF,GDI1,USP2,HYAL2,LCE4A |
| transcription factor binding | HDAC4,SORBS3,RELA,CSNK2B,ARNT,SIRT1,HMGA1,TLE1,THRA,CEBPA |
| zinc ion binding | NR2E3,PTER,MORC2B,KAT7A,MARCH7,SCEL,PGLYRP1,RASGRP1,ZFAND3,MECR |
Interacting Protein
PRICKLE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRICKLE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRICKLE1.
Rest;PRPF31;UTP14C;Smurf2;DVL2;DVL3;Pard6a;RASSF10
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