PRF1
-
Official Full Name
perforin 1 (pore forming protein) -
Overview
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] -
Synonyms
PRF1;perforin 1 (pore forming protein);P1;PFP;FLH2;PFN1;HPLH2;perforin-1;cytolysin;lymphocyte pore forming protein;lymphocyte pore-forming protein
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Yeast
- Insect Cell
- In Vitro Cell Free System
- E. coli
- Human Cytotoxic Granules of YT Cell
- His
- His&GST
- Non
- GST
- His&T7
- His&MBP
- His&SUMO
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PRF1-1942H | Recombinant Human PRF1, His-tagged | E.coli | Human | His | 247-555aa | |
| Prf1-25M | Recombinant Mouse Prf1 protein, His/GST-tagged | E.coli | Mouse | His&GST | 40-355 a.a. | |
| PRF1-158H | Active Recombinant Full Length Human PRF1 protein | E.coli | Human | His | Full L. 22-555 a.a. |
|
| PRF1-25H | Recombinant Human PRF1 protein, His/GST-tagged | E.coli | Human | His&GST | 32-316 a.a. |
|
| PRF1-29996TH | Recombinant Human PRF1 | Wheat Germ | Human | Non | 95 amino acids |
|
| PRF1-30288TH | Recombinant Full Length Human PRF1 | Wheat Germ | Human | GST | Full L. 534 amino acids |
|
| PRF1-326H | Recombinant Human PRF1 | Mammalian Cell | Human | His |
|
|
| Prf1-6804R | Recombinant Rat Prf1 protein, His & T7-tagged | E.coli | Rat | His&T7 | Ala120~Asp353 |
|
| PRF1-2873HCL | Recombinant Human PRF1 293 Cell Lysate | HEK293 | Human | Non |
|
|
| PRF1-01H | Recombinant Human PRF1 Protein, His-Tagged | E.coli | Human | His | 22-555 a.a. |
|
| PRF1-192M | Recombinant Mouse PRF1 protein, His-tagged | E.coli | Mouse | His | 21-554aa |
|
| PRF1-1931M | Recombinant Mouse PRF1 Protein (21-554 aa), His-tagged | Yeast | Mouse | His | 21-554 aa |
|
| PRF1-2252H | Recombinant Full Length Human PRF1 protein | Insect Cell | Human | His&MBP | Full L. 22-555 a.a. |
|
| PRF1-26H | Recombinant Full Length Human PRF1 protein | E.coli | Human | His&SUMO | Full L. 22-555 a.a. |
|
| PRF1-3230M | Recombinant Mouse PRF1 protein, His-tagged | E.coli | Mouse | His | Val40~Lys355 |
|
| PRF1-3904H | Recombinant Human PRF1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| PRF1-3904H-B | Recombinant Human PRF1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
||
| PRF1-392HF | Recombinant Full Length Human PRF1 Protein | In Vitro Cell Free System | Human | Full L. 534 amino acids |
|
|
| PRF1-51H | Recombinant Human perforin 1 Protein, His tagged | E. coli | Human | His | 351-555aa |
|
| PRF1-55H | Native Human Perforin | Human Cytotoxic Granules of YT Cell | Human | Non |
|
|
| PRF1-5976H | Recombinant Human PRF1 Protein (Gln411-Gly531), N-His tagged | E.coli | Human | His | Gln411-Gly531 |
|
| PRF1-738R | Recombinant Rat PRF1 Protein (25-554 aa), His-tagged | E.coli | Rat | His | 25-554 aa |
|
Involved Pathway
PRF1 involved in several pathways and played different roles in them. We selected most pathways PRF1 participated on our site, such as Natural killer cell mediated cytotoxicity,Type I diabetes mellitus,Autoi, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Graft-versus-host disease | HLA-DOA,H2-AB1,KLRD1,FASLG,IFNG,HLA-DMA,CD28,Il2,KIR2DL3,Fasl |
| Natural killer cell mediated cytotoxicity | CD244,KIR2DL3,IFNGR1,TNFSF10,ITGB2,SHC3,PRKCB,TNFRSF10A,Fasl,IFNA8 |
| Autoi | IFNA5,Ifna15,IL4,HLA-DQB1,HLA-DRA,TSHR,IFNA2,IFNA12,H2-Q10,H2-AA |
| Viral myocarditis | HLA-DPA1,MYH7,H2-Q10,HLA-C,RAC1,CD28,CASP9,RAC3,RAC2,LAMA2 |
| ne thyroid disease | Fasl,HLA-DRB5,IFNA6,H2-AA,HLA-DRB1,HLA-F,IFNA21,HLA-DMB,H2-Q10,IFNA5 |
| Allograft rejection | HLA-DQA2,MICA,HLA-DMB,IL12B,TNF,HLA-B,HLA-DPB1,HLA-F,HLA-A,HLA-DQB1 |
| Type I diabetes mellitus | GAD2,HLA-DMB,CD80,H2-AA,Fasl,ICA1,IL1A,PTPRN,HLA-DOB,HLA-F |
Protein Function
PRF1 has several biochemical functions, for example, calcium ion binding,protein binding,wide pore channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRF1 itself. We selected most functions PRF1 had, and list some proteins which have the same functions with PRF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | HEG,PCDHGA10,UMOD,GUCA1D,CAPN12,FKBP10B,PCDHB7,PCDH2G13,FSTL1B,CUBN |
| protein binding | AKR1C1,ZBTB32,VWF,CTSL1,ARHGAP33,DYNAP,EAF1,GTF2H2C,DDX39A,TRIM67 |
| wide pore channel activity | PANX1A,PANX2,PANX1B |
Interacting Protein
PRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRF1.
KRT31;SRGN;GZMB;ompC;DDX24
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References
- Balada, E; Castro-Marrero, J; et al. Clinical and serological findings associated with the expression of ITGAL, PRF1, and CD70 in systemic lupus erythematosus. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 32:113-116(2014).
- Ceccarelli, F; D'Alfonso, S; et al. The role of eight polymorphisms in three candidate genes in determining the susceptibility, phenotype, and response to anti-TNF therapy in patients with rheumatoid arthritis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 30:939-942(2012).
