PREX1
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Official Full Name
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 -
Overview
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs).It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. -
Synonyms
PREX1;phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1;phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein;KIAA1415;P REX1;ptdIns(3,4,5)-dependent Rac exchanger 1;P-REX1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PREX1-13334M | Recombinant Mouse PREX1 Protein | Mammalian Cell | Mouse | His |
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| PREX1-7078M | Recombinant Mouse PREX1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PREX1-7078M-B | Recombinant Mouse PREX1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PREX1 involved in several pathways and played different roles in them. We selected most pathways PREX1 participated on our site, such as Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PREX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | PTK2,PPBP,FGR,CCL22,GRK7,CCL21B,PIK3CA,GNG12,GRB2,AKT1 |
Protein Function
PREX1 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity,guanyl-nucleotide exchange factor activity,phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PREX1 itself. We selected most functions PREX1 had, and list some proteins which have the same functions with PREX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rho guanyl-nucleotide exchange factor activity | ARHGEF28,ITSN1,BCR,ARHGEF3L,NET1,PLEKHG3,RASGRF2B,ARHGEF40,FGD5,KALRN |
| guanyl-nucleotide exchange factor activity | ANKRD27,RASGEF1C,DOCK4,SPATA13,TBXAS1,P2RY12,FNIP1,RIC8B,TRIO,ARFGEF2 |
| phospholipid binding | DGKA,NBEA,PLA2G7,WDFY4,ABCA1,APOA5,CPS1,MTAP1B,ARHGAP26,AGAP1 |
Interacting Protein
PREX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PREX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PREX1.
Abi1
PREX1 Related Signal Pathway
Resources
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References
- Hodakoski, C; Hopkins, BD; et al. Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:155-160(2014).
- Ebi, H; Costa, C; et al. PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110:21124-21129(2013).
