PRAME
-
Official Full Name
preferentially expressed antigen in melanoma -
Overview
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene. -
Synonyms
PRAME;preferentially expressed antigen in melanoma;MAPE;melanoma antigen preferentially expressed in tumors;cancer/testis antigen 130;CT130;4930534P07Rik;OIP 4;OIP-4;OIP4;OPA interacting protein 4;Opa interacting protein OIP4;OPA-interacting protein 4;PRAME_HUMAN;Preferentially expressed antigen of melanoma;RP23-250F8.3;Opa-interacting protein OIP4
Recombinant Proteins
- Human
- E.coli
- HEK293
- Yeast
- Mammalian Cells
- His
- His&GST
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
PRAME involved in several pathways and played different roles in them. We selected most pathways PRAME participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRAME were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PRAME has several biochemical functions, for example, protein binding,retinoic acid receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRAME itself. We selected most functions PRAME had, and list some proteins which have the same functions with PRAME. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| retinoic acid receptor binding | NSD1,ACTN4,PRMT2,MED1,PRAMEF10,PRAMEF2,CTBP2,CNOT1,SNW1,PRAMEF1 |
| protein binding | RBM41,NOP56,IL13RA1,NTSR1,LLGL1,NOS1,ZNF69,LIMS3L,RFX4,RIPPLY1 |
Interacting Protein
PRAME has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRAME here. Most of them are supplied by our site. Hope this information will be useful for your research of PRAME.
CUL2;TCEB1;TCEB2;b4dyc6_human;PSMD2;HSP90AB1
Resources
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References
- Luetkens, T; Kobold, S; et al. Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation. CANCER IMMUNOLOGY IMMUNOTHERAPY 63:1151-1162(2014).
- Hemminger, JA; Toland, AE; et al. Expression of cancer-testis antigens MAGEA1, MAGEA3, ACRBP, PRAME, SSX2, and CTAG2 in myxoid and round cell liposarcoma. MODERN PATHOLOGY 27:1238-1245(2014).
