PPRC1
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Official Full Name
peroxisome proliferator-activated receptor gamma, coactivator-related 1 -
Overview
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] -
Synonyms
PPRC1;peroxisome proliferator-activated receptor gamma, coactivator-related 1;PRC;peroxisome proliferator-activated receptor gamma coactivator-related protein 1;PGC-1-related coactivator
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPRC1-13280M | Recombinant Mouse PPRC1 Protein | Mammalian Cells | Mouse | His |
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| PPRC1-7049M | Recombinant Mouse PPRC1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PPRC1-7049M-B | Recombinant Mouse PPRC1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PPRC1 involved in several pathways and played different roles in them. We selected most pathways PPRC1 participated on our site, such as Mitochondrial Gene Expression,Mitochondrial biogenesis,Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPRC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial biogenesis | POLRMT,ESRRA,PPARGC1B,MTERF,C10orf2,POLG2,TFB1M,TFB2M,GABPB1,GABPA |
| Organelle biogenesis and maintenance | MRPL40,TMEM216,BBS9,LZTFL1,KIF3CB,IFT22,TTBK2,RABL5,RP2,MRPL38 |
| Mitochondrial Gene Expression | POLRMT,TFB1M,MTERFD1,TFB2M,PPARGC1B,ESRRA |
| Transcriptional activation of mitochondrial biogenesis | GABPB1,POLRMT,POLG2,TFB1M,GABPA,MTERF,C10orf2 |
Protein Function
PPRC1 has several biochemical functions, for example, RNA binding,RNA polymerase II transcription cofactor activity,ligand-dependent nuclear receptor transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPRC1 itself. We selected most functions PPRC1 had, and list some proteins which have the same functions with PPRC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription cofactor activity | MED30,MED22,MED4,MED13A,NKX2-5,THRAP3,MED10,MED14,PPARGC1A,MED24 |
| poly(A) RNA binding | HNRPDL,RBM47,GNB2L1,DCAF13,DIMT1,FNDC3B,HDAC2,TSNAX,DHX33,PUM1 |
| transcription factor binding | SIRT1,PAXBP1,HTT,NFIA,SLC26A5,FOXA3,E2F5,HOXA7,KAT2B,SP100 |
| ligand-dependent nuclear receptor transcription coactivator activity | PRKCB,ACTN1,CARM1,NCOA2,MED14,SFR1,FGF2,SLC30A9,PKN1,NCOA3 |
| nucleotide binding | HNRNPD,RHOAD,ARL4CB,ABCF2A,CELF6,SRSF2B,RBM7,RCAN2,RHOBTB2A,RBM22 |
| nucleic acid binding | RBM44,SP8A,ZNF143B,KLF12A,EAR3,GLIS3,WT1A,HNRPKL,ZFP583,PEG3 |
| RNA binding | THUMPD2,RPL27A,RPL26,DIS3L,BICC1,EIF2S1B,SNRPD1,SUPV3L1,CAPRIN2,ZFML |
Interacting Protein
PPRC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPRC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPRC1.
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