PPP2R5B
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Official Full Name
protein phosphatase 2, regulatory subunit B, beta -
Overview
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. -
Synonyms
PPP2R5B;protein phosphatase 2, regulatory subunit B, beta;protein phosphatase 2, regulatory subunit B (B56), beta isoform , protein phosphatase 2, regulatory subunit B, beta isoform;serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform;B56B;FLJ35411;PP2A;B subunit;B beta isoform;B56 beta isoform;PR61 beta isoform;R5 beta isoform;PR61B;serine/threonine protein phosphatase 2A;56 kDa regulatory subunit;beta isoform;PP2A B subunit isoform B-beta;PP2A B subunit isoform R5-beta;PP2A B subunit isoform B56-beta;PP2A B subunit isoform PR61-beta;protein phosphatase 2, regulatory subunit B, beta isoform;serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, beta isoform
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPP2R5B-3704H | Recombinant Human PPP2R5B protein, GST-tagged | E.coli | Human | GST | 51-106 aa | |
| PPP2R5B-2918HCL | Recombinant Human PPP2R5B 293 Cell Lysate | HEK293 | Human | Non |
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| PPP2R5B-1004H | Recombinant Human PPP2R5B Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Ppp2r5b-5079M | Recombinant Mouse Ppp2r5b Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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Involved Pathway
PPP2R5B involved in several pathways and played different roles in them. We selected most pathways PPP2R5B participated on our site, such as mRNA surveillance pathway,Sphingolipid signaling pathway,Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dopaminergic synapse | ATF6B,AKT2,GSK3B,PPP3CA,ITPR1,GNG3,PRKCB,PPP1CC,PPP2R1B,PPP2R2A |
| Adrenergic signaling in cardiomyocytes | ADCY1,PPP2R2C,MYL2B,AGTR1B,KCNE1,GNAI2,MAPK11,NETO2,ADRB1,CALM3B |
| PIK-Akt signaling pathway | PDGFRA,TCL1A,Il6ra,GNG11,GNG10,IL6,RXRA,FGFR2,FGF3,FGF11 |
| Oocyte meiosis | FBXW11,PPP2R5EB,IGF1RB,CUL1,MAD2L1,CDC27,SMC1A,CDC20,MAPK3,YWHABA |
| mRNA surveillance pathway | CSTF2T,CPSF7,NCBP2,CPSF5,BCL2L2-PABPN1,CPSF3,NCBP1,SMG7,GSPT1L,UPF3B |
| AMPK signaling pathway | SCD,RAB11B,SLC2A4,CPT1B,PPP2R1A,CREB5,PCK1,MAP3K7,CPT1A,GYS2 |
| Sphingolipid signaling pathway | LASS5,ROCK2,PIK3R2,PIK3CG,ABCC1,FCER1A,RAC2,PLCB1,TRADD,PRKCG |
Protein Function
PPP2R5B has several biochemical functions, for example, protein binding,protein phosphatase type 2A regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R5B itself. We selected most functions PPP2R5B had, and list some proteins which have the same functions with PPP2R5B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein phosphatase type 2A regulator activity | PPP2R2A,PPME1,ARPP19,PPP2R5EB,PPP2R2B,PPP2R5A,PPP2R2CA,ENSAA,PPP2R2BB,PPP2R5CB |
| protein binding | TIPIN,CLK2,GAGE5,MED7,ABCF3,FOXR1,LNX1,SID4,CST1,INTS5 |
Interacting Protein
PPP2R5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R5B here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R5B.
PPP2CA;IER3;CHEK2;Ppp2ca;arcB;DZIP1;PPP2R1A;KSR1;ARHGEF2
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References
- Yang, HX; Jin, GL; et al. Screening and identification of proteins interacting with nucleostemin. WORLD JOURNAL OF GASTROENTEROLOGY 11:4812-4814(2005).
- Fleming, I; Busse, R; et al. Tyrosine phosphorylation and bradykinin-induced signaling in endothelial cells. AMERICAN JOURNAL OF CARDIOLOGY 80:A102-A109(1997).
