PPP2R1B

  • Official Full Name

    protein phosphatase 2, regulatory subunit A, beta

  • Overview

    This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.

  • Synonyms

    PPP2R1B;protein phosphatase 2, regulatory subunit A, beta;protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform , protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform;serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform;PP2A A beta;PP2A Abeta;PR65B;protein phosphatase 2A;regulatory subunit A;beta isoform;2AAB_HUMAN;beta isoform of regulatory subunit A, protein phosphatase 2;PP2A subunit A isoform PR65-beta;PP2A subunit A isoform R1-beta;PP2A, subunit A, PR65 beta isoform;PP2A, subunit A, R1 beta isoform;protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform;protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform;protein phosphatase 2, structural/regulatory subunit A, beta isoform;serine/threonine protein phosphatase 2A 65 kDa regulatory subunit A, beta isoform;serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, beta isoform;PP2A, subunit A, R1-beta isoform;PP2A, subunit A, PR65-beta isoform;protein phosphatase 2, structural/regulatory subunit A, beta;PP2A-Abeta

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PPP2R1B-1915H Recombinant Human PPP2R1B, GST-tagged E.coli Human GST C-term-348aa
PPP2R1B-1432Z Recombinant Zebrafish PPP2R1B Mammalian Cell Zebrafish His
PPP2R1B-27569TH Recombinant Human PPP2R1B Wheat Germ Human Non 601 amino acids
PPP2R1B-4633R Recombinant Rat PPP2R1B Protein Mammalian Cell Rat His
PPP2R1B-2925HCL Recombinant Human PPP2R1B 293 Cell Lysate HEK293 Human Non
PPP2R1B-414HF Recombinant Full Length Human PPP2R1B Protein In Vitro Cell Free System Human Full L. 601 amino acids
PPP2R1B-4292R Recombinant Rat PPP2R1B Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
PPP2R1B-4292R-B Recombinant Rat PPP2R1B Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    PPP2R1B involved in several pathways and played different roles in them. We selected most pathways PPP2R1B participated on our site, such as mRNA surveillance pathway,Sphingolipid signaling pathway,Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AMPK signaling pathway IGF1,PCK1,CREB1,PPARG,IRS1,GYS1,PPP2R3A,CCND1,IGF1R,PRKAB1
    PIK-Akt signaling pathway IGF1R,ITGB8,BCL2L1,PPP2R5D,HSP90AA1,RAF1,G6PC3,GNG8,COL27A1,PRKAA1
    Chagas disease (American trypanosomiasis) PIK3CD,GNAS,MAPK1,PIK3CA,PPP2R2C,NOS2,GNAI1,MYD88,CD3E; CD3D,CD3D
    Tight junction MYL9B,JAM3,CLDN5A,ACTN4,CRB3A,SHROOM3,MYL12.1,ACTN3,GNAI3,MYH1A
    mRNA surveillance pathway FIP1L1B,PABPC1B,UPF3B,PPP2R5D,PPP2R2D,MSI1,PPP2R5EB,CPSF5,PNN,PPP2R5C
    Oocyte meiosis CPEB2,PPP2R5D,INSB,RPS6KA3B,REC8,CALM1,PRKACA,CALM3,CDC23,PGR
    Dopaminergic synapse ATF4,MAOB,CALY,PRKACA,GNAQ,ARNTL,AKT2,GNAI3,CREB3L4,GNB1
    Adrenergic signaling in cardiomyocytes CALM4,ADCY2B,CAMK2A,MAPK1,CALML5,TPMA,PLN,PPP2R5D,ATP2A2,VMHC
    Hepatitis C LDLR,Ifna11,PIK3CD,MAPK11,IFNA17,GRB2,ARAF,IFNA16,AKT2,IFNA5

    Protein Function

    PPP2R1B has several biochemical functions, for example, protein binding,protein phosphatase type 2A regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R1B itself. We selected most functions PPP2R1B had, and list some proteins which have the same functions with PPP2R1B. You can find most of the proteins on our site.

    Function Related Protein
    protein binding MOAP1,GRN,ASIC2,SENP6,NPC2,SPANXD,TARBP2,SH2B3,SHE,CDC42EP1
    protein phosphatase type 2A regulator activity ARPP19,PPP2R5A,PPME1,PPP2R5EA,PPP2R5CB,SET,ENSA,PPP2R4,IGBP1,PPP2R5B

    Interacting Protein

    PPP2R1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R1B.

    PPP2CA;STRN3;PPP2R5D;STRN;PPP2R5E

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