PPP1R3B
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Official Full Name
protein phosphatase 1, regulatory subunit 3B -
Overview
This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein. -
Synonyms
PPP1R3B;protein phosphatase 1, regulatory subunit 3B;protein phosphatase 1, regulatory (inhibitor) subunit 3B;protein phosphatase 1 regulatory subunit 3B;FLJ14005;GL;hepatic glycogen targeting subunit;G(L);PP1 subunit R4;PPP1R4;FLJ34675;Hepatic glycogen targeting protein phosphatase 1 regulatory subunit GL;Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL;PPR3B_HUMAN;Protein phosphatase 1 regulatory (inhibitor) subunit 3B;Protein phosphatase 1 regulatory subunit 4;Protein phosphatase 1 subunit 4;Protein phosphatase 1 subunit GL;R4;OTTHUMP00000159678;OTTHUMP00000224512;hepatic glycogen-targeting subunit, G(L)
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPP1R3B-1909H | Recombinant Human PPP1R3B, GST-tagged | E.coli | Human | GST | 1-285aa | |
| PPP1R3B-11984Z | Recombinant Zebrafish PPP1R3B | Mammalian Cell | Zebrafish | His |
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| PPP1R3B-13238M | Recombinant Mouse PPP1R3B Protein | Mammalian Cell | Mouse | His |
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| PPP1R3B-2330H | Recombinant Human PPP1R3B, His-tagged | E.coli | Human | His | 308aa |
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| PPP1R3B-4626R | Recombinant Rat PPP1R3B Protein | Mammalian Cell | Rat | His |
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| PPP1R3B-2935HCL | Recombinant Human PPP1R3B 293 Cell Lysate | HEK293 | Human | Non |
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| PPP1R3B-2618H | Recombinant Human PPP1R3B Protein, His-tagged | E.coli | Human | His | Met1-Tyr285 |
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| PPP1R3B-4285R | Recombinant Rat PPP1R3B Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PPP1R3B-4285R-B | Recombinant Rat PPP1R3B Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PPP1R3B-7023M | Recombinant Mouse PPP1R3B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PPP1R3B-7023M-B | Recombinant Mouse PPP1R3B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PPP1R3B involved in several pathways and played different roles in them. We selected most pathways PPP1R3B participated on our site, such as Insulin signaling pathway,Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1R3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | MGEA5,PPP1CA,G6PCA.1,CD36,RPS6KA3,GFPT1,G6PC2,SLC27A1B,PIK3R3A,CREB1A |
| Insulin signaling pathway | SH2B2,GRB2B,IKBKB,EIF4E2RS1,EIF4EA,CALM4,PHKA2,PIK3CB,PPP1CAB,GSK3B |
Protein Function
PPP1R3B has several biochemical functions, for example, enzyme binding,phosphoprotein phosphatase activity,protein phosphatase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1R3B itself. We selected most functions PPP1R3B had, and list some proteins which have the same functions with PPP1R3B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | MSH3,UGT1A6,SUDS3,THRB,SCN5A,DAXX,PTPLA,DDX5,PHKG1,PRMT1 |
| phosphoprotein phosphatase activity | DUSP28,PPM1DB,PTPRK,PPP3CCB,PPM1BB,DUSP16,DUSP9,PPP4CA,PTPRQ,PPP3CC |
| protein phosphatase regulator activity | PPP4R4,PPP1R3CB,PPP1R3CA,PPP1R3C,SHOC2 |
Interacting Protein
PPP1R3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1R3B here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1R3B.
PYGM;IFNAR2;PPP1CA;PPP1CB;PLEC;NUP153
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References
- Lin, YC; Chang, PF; et al. Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals. AMERICAN JOURNAL OF CLINICAL NUTRITION 99:869-874(2014).
- Hernaez, R; McLean, J; et al. Association Between Variants in or Near PNPLA3, GCKR, and PPP1R3B With Ultrasound-Defined Steatosis Based on Data From the Third National Health and Nutrition Examination Survey. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 11:1183-U203(2013).
