PPP1R15A
-
Official Full Name
protein phosphatase 1, regulatory subunit 15A -
Overview
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. -
Synonyms
PPP1R15A;protein phosphatase 1, regulatory subunit 15A;protein phosphatase 1, regulatory (inhibitor) subunit 15A;protein phosphatase 1 regulatory subunit 15A;GADD34;growth arrest and DNA damage inducible 34;growth arrest and DNA-damage-inducible 34
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Wheat Germ
- HEK293
- Mammalian Cells
- Yeast
- E.coli
- GST
- Myc&DDK
- His
- Non
- Flag
- His&Fc&Avi
Involved Pathway
PPP1R15A involved in several pathways and played different roles in them. We selected most pathways PPP1R15A participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1R15A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | EIF2AK4,UBE2J2,HSPA1B,PARK2,PLAA,MAP3K5,SEC61A1,SEC23B,UBE2D3,CRYAA |
Protein Function
PPP1R15A has several biochemical functions, for example, protein binding,protein kinase binding,protein phosphatase 1 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1R15A itself. We selected most functions PPP1R15A had, and list some proteins which have the same functions with PPP1R15A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF490,SLC30A1,GLRX3,C9orf116,DYNLL2,CCT4,CD209,SPSB3,DHX36,GRAP |
| protein phosphatase type 1 regulator activity | PHACTR1,UBXN2A,NSFL1C,UBXN2B,KCNS1,PHACTR4B,WBP11,PPP1R7,PHACTR3A,PPP1R8 |
| protein kinase binding | LLGL1,B4GALT1,GRIN2A,GHR,GATA6,NBEA,CDH2,CCNL1A,RAD9,TP73 |
| protein phosphatase type 1 activator activity | PHACTR4B,PHACTR4 |
| protein phosphatase 1 binding | PPP1R9B,TCTEX1D4,FER,PPP1R11,PHACTR3A,PHACTR1,SHOC2,PHACTR4,PHACTR3,PHACTR4B |
Interacting Protein
PPP1R15A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1R15A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1R15A.
CTBP2;PPP1R1A;Dlg4;microcystin-lr;MYC;POU3F3;BCAR1;PPP1CA;trpE;q81l21_bacan;secA2;q81w74_bacan;ZNF512B
Resources
Related Services
Related Products
References
- Ohri, SS; Mullins, A; et al. Inhibition of GADD34, the Stress-Inducible Regulatory Subunit of the Endoplasmic Reticulum Stress Response, Does Not Enhance Functional Recovery after Spinal Cord Injury. PLOS ONE 9:-(2014).
- Yong, KJ; Milenic, DE; et al. Impact of alpha-Targeted Radiation Therapy on Gene Expression in a Pre-Clinical Model for Disseminated Peritoneal Disease when Combined with Paclitaxel. PLOS ONE 9:-(2014).
