PPP1R12A
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Official Full Name
protein phosphatase 1, regulatory subunit 12A -
Overview
Protein phosphatase 1 (PP1) is a ubiquitous eukaryotic protein serine/threonine phosphatase involved in the regulation of various cell functions. Substrate specificity is determined by the binding of a regulatory subunit to the PP1 catalytic subunit (PP1c -
Synonyms
PPP1R12A;protein phosphatase 1, regulatory subunit 12A;MYPT1, protein phosphatase 1, regulatory (inhibitor) subunit 12A;protein phosphatase 1 regulatory subunit 12A;M130;MBS;myosin binding subunit;myosin phosphatase targeting subunit 1;myosin phosphatase, target subunit 1;myosin phosphatase-targeting subunit 1;protein phosphatase myosin-binding subunit;protein phosphatase 1, regulatory (inhibitor) subunit 12A;MYPT1;MGC133042
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Rhesus macaque
- Rat
- Chicken
- Mammalian Cell
- HEK293
- E.coli
- Mamanlian cells
- HEK293T
- His
- Myc&DDK
- Non
- Flag
- His&Fc&Avi
Involved Pathway
PPP1R12A involved in several pathways and played different roles in them. We selected most pathways PPP1R12A participated on our site, such as cGMP-PKG signaling pathway,cAMP signaling pathway,Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1R12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vascular smooth muscle contraction | RAF1B,PLA2G2D,PRKG1A,PPP1R14AA,ARAF,PPP1CBL,KCNMB1,ADORA2AA,RHOAA,PLA2G2F |
| Regulation of Actin Cytoskeleton | PIP5K1BB,FGF6B,RAF1A,SOS1,PDGFD,LIMK1A,MYL12.1,GSNB,CHRM2A,RAC3A |
| cGMP-PKG signaling pathway | ROCK2,LOC100328615,MYLK4,GNA12,ATP2A3,GNAI2,CREB3L2,PDE3A,BAD,RHOA |
| Oxytocin signaling pathway | HRAS,CALML5,NFATC2,CACNA2D1,PLCB2,GNAI3,CACNG4,PPP1CB,PRKCA,GUCY1B3 |
| Platelet activation | VAMP8,COL27A1,MYL12B,PRKACG,PTGS1,TBXAS1,PRKACB,AKT2,GUCY1B3,TBXA2R |
| cAMP signaling pathway | HTR4,GRIN2A,MC2R,PIK3CB,GIPR,RAC1,ATP1A3,CALM4,PAK1,CREB3L3 |
| Proteoglycans in cancer | WNT6,FN1,WNT9A,CD63,MAPK11,ANK2,ITGB3,TLR2,FLNA,MAPK13 |
| Focal adhesion | RAF1,RHOA,BCL2,PARVG,ITGA1,VEGFA,VAV3B,PPP1CBL,LAMC1,PTK2 |
Protein Function
PPP1R12A has several biochemical functions, for example, 14-3-3 protein binding,enzyme inhibitor activity,phosphatase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1R12A itself. We selected most functions PPP1R12A had, and list some proteins which have the same functions with PPP1R12A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | OLFR998,VALOPA,MAPKAPK2B,TAS2R144,TAAR6,ATP2C1,TRIM38,AGTR1B,MAPKAPK2A,TAS2R134 |
| 14-3-3 protein binding | HDAC7A,HDAC7,TSC2,KIF13B,SRPK2,PRKCE,AANAT,ZFP36,RPTOR,DDIT4 |
| protein kinase binding | EEF2,RFFL,FBXO7,FAM83D,STAT3,CD24,SHC3,ADCY6,EPHA1,RAB8A |
| enzyme inhibitor activity | FRY,OAZ2A,KIAA1967,OAZ2B,HSPBP1,CALU,WDTC1,TAE1,PDE6H,CSN2 |
| protein binding | CACNA2D1A,EP400,RECK,NCS1,AKT1S1,SLC39A7,ODF1,EWSR1A,KCNG4,FAM82A2 |
| phosphatase regulator activity | SBF1,MTMR12,PPP1R12B,BMP2K |
Interacting Protein
PPP1R12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1R12A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1R12A.
DAPK3;DMPK;PPP1CB;MPRIP;Cdc42bpa;PTPRJ;Rock2;Cdc42bpb;Stag2;FOS;FYN
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References
- Zhang, XM; Ma, DJ; et al. Quantitative phosphoproteomics reveals novel phosphorylation events in insulin signaling regulated by protein phosphatase 1 regulatory subunit 12A. JOURNAL OF PROTEOMICS 109:63-75(2014).
- Geetha, T; Langlais, P; et al. Protein phosphatase 1 regulatory subunit 12A and catalytic subunit delta, new members in the phosphatidylinositide 3 kinase insulin-signaling pathway. JOURNAL OF ENDOCRINOLOGY 214:437-443(2012).
