PPIP5K2
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Official Full Name
diphosphoinositol pentakisphosphate kinase 2 -
Overview
Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell;signaling molecules. HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24);activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et;al., 2007 (PubMed 17690096)). -
Synonyms
PPIP5K2;diphosphoinositol pentakisphosphate kinase 2;HISPPD1, histidine acid phosphatase domain containing 1;inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2;KIAA0433;VIP2;hsVIP2;VIP1 homolog 2;insP6 and PP-IP5 kinase 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPIP5K2-13193M | Recombinant Mouse PPIP5K2 Protein | Mammalian Cell | Mouse | His |
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| PPIP5K2-2613H | Recombinant Human PPIP5K2 Protein, His-tagged | E.coli | Human | His | Gly145-Lys456 |
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| PPIP5K2-2671H | Recombinant Human PPIP5K2 Protein, His-tagged | E.coli | Human | His |
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| PPIP5K2-6989M | Recombinant Mouse PPIP5K2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PPIP5K2-6989M-B | Recombinant Mouse PPIP5K2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PPIP5K2 involved in several pathways and played different roles in them. We selected most pathways PPIP5K2 participated on our site, such as Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPIP5K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphatidylinositol signaling system | PRKCB,PI4KA,PLCD1,PLCZ1,PRKCA,INPP5B,PIP5K1AB,PIP5K1B,PTENB,PTEN |
Protein Function
PPIP5K2 has several biochemical functions, for example, ATP binding,acid phosphatase activity,diphosphoinositol-pentakisphosphate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPIP5K2 itself. We selected most functions PPIP5K2 had, and list some proteins which have the same functions with PPIP5K2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| diphosphoinositol-pentakisphosphate kinase activity | PPIP5K1 |
| ATP binding | DDX5,HELLS,AK7,CDK11B,DGUOK,HSP70,GC2,CDC42BPB,UBE2D1B,DDX31 |
| inositol hexakisphosphate 5-kinase activity | PPIP5K1,IP6K2,IP6K3,IP6K1 |
| inositol hexakisphosphate 1-kinase activity | IP6K1,PPIP5K1,IP6K3,IP6K2 |
| acid phosphatase activity | ACP1,ACPT,MINPP1A,MINPP1,PAPL,MINPP1B,ACP5,ACPP,ACPL2,PXYLP1 |
| transferase activity | UGT1AB,BMPR1BA,CKMT1,GLT8D1,AGPAT9L,ACAA1A,DCLK2,PRKACBB,FUT9D,OXCT2A |
| inositol hexakisphosphate 3-kinase activity | PPIP5K1,IP6K3,IP6K2,IP6K1 |
| kinase activity | CKMB,DCLK3,RIPK4,PKN1B,IGF1RB,FGFR1A,CKBA,CAMK1DA,EPHB4A,DNAJC3B |
| nucleotide binding | TGFBR1A,SGK2B,GNAT1,HINT1,EIF2S3Y,ABCB4,NCL,HNRNPA2B1,SEPT9A,EXOSC10 |
Interacting Protein
PPIP5K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPIP5K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPIP5K2.
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References
- Williams, SP; Gillaspy, GE; et al. Biosynthesis and possible functions of inositol pyrophosphates in plants. FRONTIERS IN PLANT SCIENCE 6:-(2015).
- Capolicchio, S; Wang, HC; et al. Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53:9508-9511(2014).
