PPIL2
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Official Full Name
peptidylprolyl isomerase (cyclophilin)-like 2 -
Overview
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PPIL2;peptidylprolyl isomerase (cyclophilin)-like 2;peptidyl-prolyl cis-trans isomerase-like 2;Cyp 60;FLJ39930;CYC4;Cyclophilin 60;Cyclophilin 60kDa;Cyclophilin like protein Cyp 60;Cyclophilin-60;Cyclophilin-like protein Cyp-60;CYP60;hCyP 60;MGC33174;MGC787;Peptidyl prolyl cis trans isomerase like 2;Peptidylprolyl cis trans isomerase;Peptidylprolyl isomerase cyclophilin like 2;PPIase;PPIL2_HUMAN;Rotamase;Rotamase PPIL2;cyclophilin, 60kDa;peptidylprolyl cis-trans isomerase;Cyp-60;hCyP-60
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPIL2-1888H | Recombinant Human PPIL2, GST-tagged | E.coli | Human | GST | C-term-300aa | |
| PPIL2-11225Z | Recombinant Zebrafish PPIL2 | Mammalian Cell | Zebrafish | His |
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| PPIL2-13188M | Recombinant Mouse PPIL2 Protein | Mammalian Cell | Mouse | His |
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| PPIL2-2030H | Recombinant Human PPIL2, His-tagged | E.coli | Human | His |
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| PPIL2-2359C | Recombinant Chicken PPIL2 | Mammalian Cell | Chicken | His |
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| PPIL2-537H | Recombinant Human PPIL2 protein, His-tagged | E.coli | Human | His | Gly280-Pro457 |
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| PPIL2-2967HCL | Recombinant Human PPIL2 293 Cell Lysate | HEK293 | Human | Non |
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| PPIL2-0509H | Recombinant Human PPIL2 Protein (G2-W520), Tag Free | E.coli | Human | Non | G2-W520 |
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| PPIL2-0510H | Recombinant Human PPIL2 Protein (G2-W520), His tagged | E.coli | Human | His | G2-W520 |
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| PPIL2-6985M | Recombinant Mouse PPIL2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PPIL2-6985M-B | Recombinant Mouse PPIL2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PPIL2 involved in several pathways and played different roles in them. We selected most pathways PPIL2 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPIL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | UBOX5,CUL3A,SOCS3,SMURF1,UBE2NB,HERC2,BTRC,UBE2A,UBE2D1B,UBE3A |
Protein Function
PPIL2 has several biochemical functions, for example, ligase activity,peptidyl-prolyl cis-trans isomerase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPIL2 itself. We selected most functions PPIL2 had, and list some proteins which have the same functions with PPIL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-ubiquitin ligase activity | UBE4B,STUB1,UBOX5,AMFR,PRPF19,UBE2K,ANAPC11,RBX1 |
| peptidyl-prolyl cis-trans isomerase activity | PPIAL4C,FKBP9,PPIAL4B,RANBP2,PPIL3,FKBP5,FKBPL,FKBP6,PPIAB,PPIH |
| ligase activity | MYLIPA,MARCH10,MKRN1,PRPF19,NHLRC1,RNF133,UHRF2,RNF14,TTC3,TTLL6 |
| protein binding | C9orf116,EIF2S2,LIN28A,MSR1,EPHB6,BCL3,UBQLN4,THOC1,BTG2,DENND2D |
| ubiquitin protein ligase activity | UHRF1,RNF181,CCNC,UBE2C,TRIP12,MYLIP,RLIM,PDZD4,HECTD1,UBE2J2 |
Interacting Protein
PPIL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPIL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPIL2.
TRIM23;ZNF830;KANSL2;PRCC;Naa15;PDGFRA;VPS26B;KLC3;Srsf1;Smad3;Ccdc12;KLC2;PIM2;BAIAP2;Racgap1
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References
- Chen, KY; Cheng, CJ; et al. Comparative studies on the proteomic expression patterns in the third- and fifth-stage larvae of Angiostrongylus cantonensis. PARASITOLOGY RESEARCH 113:3591-3600(2014).
- Beyer, N; Coulson, DTR; et al. mRNA LEVELS OF BACE1 AND ITS INTERACTING PROTEINS, RTN3 AND PPIL2, CORRELATE IN HUMAN POST MORTEM BRAIN TISSUE. NEUROSCIENCE 274:44-52(2014).
