PPEF1
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Official Full Name
protein phosphatase, EF-hand calcium binding domain 1 -
Overview
This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. -
Synonyms
PPEF1;protein phosphatase, EF-hand calcium binding domain 1;PPEF;serine/threonine-protein phosphatase with EF-hands 1;PPP7CA;protein phosphatase 7;catalytic subunit;alpha isozyme;serine/threonine protein phosphatase 7;serine/threonine-protein pho
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPEF1-1878H | Recombinant Human PPEF1, GST-tagged | E.coli | Human | GST | N-term-350aa | |
| PPEF1-3062H | Recombinant Human PPEF1 protein, His-tagged | E.coli | Human | His | 1-350 aa | |
| PPEF1-13170M | Recombinant Mouse PPEF1 Protein | Mammalian Cell | Mouse | His |
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| PPEF1-4598R | Recombinant Rat PPEF1 Protein | Mammalian Cell | Rat | His |
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| PPEF1-6474Z | Recombinant Zebrafish PPEF1 | Mammalian Cell | Zebrafish | His |
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| PPEF1-2980HCL | Recombinant Human PPEF1 293 Cell Lysate | HEK293 | Human | Non |
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| PPEF1-4257R | Recombinant Rat PPEF1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PPEF1-4257R-B | Recombinant Rat PPEF1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PPEF1-6974M | Recombinant Mouse PPEF1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PPEF1-6974M-B | Recombinant Mouse PPEF1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PPEF1 involved in several pathways and played different roles in them. We selected most pathways PPEF1 participated on our site, such as Inactivation, recovery and regulation of the phototransduction cascade,Signal Transduction,The phototransduction cascade, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Visual phototransduction | RLBP1B,ABCA4A,LRP12,RPE65A,APOM,APOA4B.2,CLPS,BCO2,RBP3,RDH10 |
| Signal Transduction | ARHGAP1,LRP10,MDK,APOC2,NPFF,STRA6,CDON,RGR,USP9X,PRC1B |
| Inactivation, recovery and regulation of the phototransduction cascade | NMT1,METAP1,NMT1B,CNGA1,RHOL,RLN1,GRK7,GUCA1E,NMT2,METAP2 |
| The phototransduction cascade | GUCA1E,NMT1A,METAP2B,METAP2,RLN1,GRK7,METAP2A,RGS9BP,NMT1B,CNGA1 |
Protein Function
PPEF1 has several biochemical functions, for example, calcium ion binding,iron ion binding,manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPEF1 itself. We selected most functions PPEF1 had, and list some proteins which have the same functions with PPEF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine phosphatase activity | PPM1A,CDC14AA,DUSP23,PPM1E,PPM1LB,UBLCP1,PPP2R2A,CTDNEP1A,PPP1CC,PPM1K |
| calcium ion binding | PPP3CA,CALB2B,ANXA4,AMY2A,SLC25A24L,SYT5A,NCAN,DHH,CABP5,PCDH2G10 |
| manganese ion binding | FEN1,HMGCL,PEPD,CDIPT,PAPOLA,PCK1,ENDOU,GALNT3,SLC11A2,MTPAP |
| iron ion binding | CYP51,NFU1,FBXL5,LEPREL2,NOS2A,HBAE1,CYP2K16,CYGB1,CYP4V8,CYP3C1L2 |
| protein binding | CITED2,LIG3,FLT3,PTPRJ,HSPA9,SECISBP2,TEN1,TIMP2,FASN,MKNK1 |
Interacting Protein
PPEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPEF1.
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References
- Yamaguchi, M; et al. The anti-apoptotic effect of regucalcin is mediated through multisignaling pathways. APOPTOSIS 18:1145-1153(2013).
- Brunet, S; Scheuer, T; et al. Increased intracellular magnesium attenuates beta-adrenergic stimulation of the cardiac Ca(V)1.2 channel. JOURNAL OF GENERAL PHYSIOLOGY 141:85-94(2013).
