POU6F2
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Official Full Name
POU class 6 homeobox 2 -
Overview
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
POU6F2;POU class 6 homeobox 2;POU domain, class 6, transcription factor 2;Retina derived POU domain factor 1;RPF 1;POU domain class 6 transcription factor 2;RPF1;Wilms tumor suppressor locus;WT 5;WT5;WTSL;OTTHUMP00000198531;OTTHUMP00000198532;retina-derived POU domain factor 1;retina-derived POU-domain factor-1;RPF-1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POU6F2-13150M | Recombinant Mouse POU6F2 Protein | Mammalian Cell | Mouse | His |
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| POU6F2-2996HCL | Recombinant Human POU6F2 293 Cell Lysate | HEK293 | Human | Non |
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| Pou6f2-5026M | Recombinant Mouse Pou6f2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| POU6F2-6960M | Recombinant Mouse POU6F2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| POU6F2-6960M-B | Recombinant Mouse POU6F2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
POU6F2 involved in several pathways and played different roles in them. We selected most pathways POU6F2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with POU6F2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
POU6F2 has several biochemical functions, for example, DNA binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POU6F2 itself. We selected most functions POU6F2 had, and list some proteins which have the same functions with POU6F2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | RREB1,RFXAP,NPAS1,IKZF5,ZFP641,HOXC6B,NR4A2B,HOXB6,FOXC2,DMRTC1B |
| DNA binding | RNF141,SET,NFYC,ZFP821,ZNF544,RYBP,MXTX1,FOXQ1A,ZNF329,SIX6B |
Interacting Protein
POU6F2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POU6F2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POU6F2.
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