POMT2
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Official Full Name
protein-O-mannosyltransferase 2 -
Overview
The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT1 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS). -
Synonyms
POMT2;protein-O-mannosyltransferase 2;protein O-mannosyl-transferase 2;A830009D15Rik;AW046274;DKFZp686G10254;Dolichyl phosphate mannose protein mannosyltransferase 2;FLJ22309;POMT 2;Protein O mannosyltransferase 2;Protein O mannosyltransferase;Putative protein O mannosyltransferase;rCG_20643;dolichyl-phosphate-mannose--protein mannosyltransferase 2;MDDGA2;MDDGB2;MDDGC2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POMT2-1857H | Recombinant Human POMT2, GST-tagged | E.coli | Human | GST | 307-602aa | |
| POMT2-13121M | Recombinant Mouse POMT2 Protein | Mammalian Cell | Mouse | His |
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| POMT2-3525R | Recombinant Rhesus monkey POMT2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| POMT2-4102Z | Recombinant Zebrafish POMT2 | Mammalian Cell | Zebrafish | His |
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| POMT2-3016HCL | Recombinant Human POMT2 293 Cell Lysate | HEK293 | Human | Non |
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| POMT2-3343R | Recombinant Rhesus Macaque POMT2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| POMT2-3343R-B | Recombinant Rhesus Macaque POMT2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| POMT2-6939M | Recombinant Mouse POMT2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| POMT2-6939M-B | Recombinant Mouse POMT2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
POMT2 involved in several pathways and played different roles in them. We selected most pathways POMT2 participated on our site, such as Other types of O-glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with POMT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Other types of O-glycan biosynthesis | B3GALTLB,B3GAT1A,B4GALT1,GLT25D1,ST6GAL2,GXYLT1B,MGAT5B,POFUT1,LFNG,POMT1 |
Protein Function
POMT2 has several biochemical functions, for example, contributes_to dolichyl-phosphate-mannose-protein mannosyltransferase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POMT2 itself. We selected most functions POMT2 had, and list some proteins which have the same functions with POMT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | PRPSAP2,PPM1K,ZFP689,KLF17,ZNF461,HSPB11,SIAH2L,CBFA2T2,RNF216,GM12824 |
| contributes_to dolichyl-phosphate-mannose-protein mannosyltransferase activity | POMT1,SDF2L1 |
Interacting Protein
POMT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POMT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POMT2.
Resources
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References
- Lommel, M; Winterhalter, PR; et al. Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesion. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110:21024-21029(2013).
- Zhang, P; Hu, HY; et al. Differential glycosylation of alpha-dystroglycan and proteins other than alpha-dystroglycan by like-glycosyltransferase. GLYCOBIOLOGY 22:235-247(2012).
