POLR2D
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Official Full Name
polymerase (RNA) II (DNA directed) polypeptide D -
Overview
This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3 untranslated region of the transcript from this gene. -
Synonyms
POLR2D;polymerase (RNA) II (DNA directed) polypeptide D;DNA-directed RNA polymerase II subunit RPB4;RBP4;RNA polymerase II subunit hsRBP4;DNA-directed RNA polymerase II 16 kDa polypeptide;DNA-directed RNA polymerase II subunit D;HSRBP4;polymerase RNA II DNA directed polypeptide D;RNA polymerase II subunit B4;RNA polymerase II subunit D;OTTHUMP00000162266;OTTHUMP00000203872;OTTHUMP00000205986;RNA polymerase II 16 kDa subunit;DNA-directed RNA p;RPB16;HSRPB4
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
POLR2D involved in several pathways and played different roles in them. We selected most pathways POLR2D participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA polymerase | POLR2J3,POLR1E,POLR2J,POLR2I,POLR3D,POLR2GL,POLR2A,POLR3A,POLR2C,POLR1B |
| Metabolic pathways | PTDSS1,UGP2B,CYP21A2,AKR1D1,ADH7,ACACB,SPTLC2A,HMGCRB,BCKDHA,STT3A |
| Epstein-Barr virus infection | YWHAG,PSMD3,GTF2E2,PSMC2,PIK3R3,NEDD4,RIPK1,POLR2J2,SPI1,IRF3 |
| Purine metabolism | GUK1A,PRPS1L1,GMPR,CANT1A,PDE7B,POLR1B,AMPD2,PDE6D,NME7,APRT |
| Huntingtons disease | REST,NDUFS2,TBP,COX6C,NDUFS4,PLCB4,POLR2A,VDAC2,DCTN2,ATP5C1 |
| Pyrimidine metabolism | DHODH,DCK,CTPS2,POLR2J2,POLA1,NME2,POLR1A,NT5C,UPP2,POLR2J3 |
Protein Function
POLR2D has several biochemical functions, for example, DNA-directed RNA polymerase activity,nucleotide binding,contributes_to single-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2D itself. We selected most functions POLR2D had, and list some proteins which have the same functions with POLR2D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to single-stranded DNA binding | IGJ,MLH1,MSH2,PMS2,MSH3,IGHM |
| translation initiation factor binding | EIF3M,DDX3X,TBL2,POLR2GL,ZNF259,LIN28A,EIF3F,RPS24,EIF3BA,CELF1 |
| DNA-directed RNA polymerase activity | POLR3G,POLR2EB,POLR2GL,POLR3B,CD3EAP,POLR2B,POLR3C,POLRMT,POLR3A,CRCP |
| nucleotide binding | APOA1BP,EIF3BA,GC2,IGF1RA,PRKCDA,HSPA4B,SEPT7A,CELF3,HINT3,ZRANB3 |
Interacting Protein
POLR2D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2D here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2D.
MED19;MED26;POLR2L;RBBP6;ssdna_dc;SUPT5H;LIMK1;POLR2G;CTR9;Med28;MED10;Rprd1b;MED9;MED29
Resources
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References
- Goede, B; Naji, S; et al. Protein-protein interactions in the archaeal transcriptional machinery - Binding studies of isolated RNA polymerase subunits and transcription factors. JOURNAL OF BIOLOGICAL CHEMISTRY 281:30581-30592(2006).
- Ren, YG; Martinez, J; et al. Identification of the active site of poly(A)-specific ribonuclease by site-directed mutagenesis and Fe2+-mediated cleavage. JOURNAL OF BIOLOGICAL CHEMISTRY 277:5982-5987(2002).
