POLR1C
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Official Full Name
polymerase (RNA) I polypeptide C, 30kDa -
Overview
The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS). -
Synonyms
POLR1C;polymerase (RNA) I polypeptide C, 30kDa;DNA-directed RNA polymerases I and III subunit RPAC1;RPA5;RPA39;RPA40;RPAC1;AC40;RPC40;RNA polymerases I and III subunit AC1;DNA-directed RNA polymerase I subunit C;DNA-directed RNA polymerases I a
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POLR1C-1838H | Recombinant Human POLR1C, GST-tagged | E.coli | Human | GST | 1-346aa | |
| POLR1C-10846Z | Recombinant Zebrafish POLR1C | Mammalian Cell | Zebrafish | His |
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| POLR1C-13088M | Recombinant Mouse POLR1C Protein | Mammalian Cell | Mouse | His |
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| POLR1C-260H | Recombinant Human POLR1C, His-tagged | E.coli | Human | His | 1-349aa |
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| POLR1C-28614TH | Recombinant Human POLR1C, His-tagged | E.coli | Human | His | 1-174 a.a. |
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| POLR1C-5009C | Recombinant Chicken POLR1C | Mammalian Cell | Chicken | His |
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| POLR1C-5010C | Recombinant Chicken POLR1C | Mammalian Cell | Chicken | His |
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| POLR1C-3041HCL | Recombinant Human POLR1C 293 Cell Lysate | HEK293 | Human | Non |
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| POLR1C-2762H | Recombinant Human POLR1C Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Polr1c-4993M | Recombinant Mouse Polr1c Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| POLR1C-6918M | Recombinant Mouse POLR1C Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| POLR1C-6918M-B | Recombinant Mouse POLR1C Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
POLR1C involved in several pathways and played different roles in them. We selected most pathways POLR1C participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA polymerase | POLR2L,POLR2J3,POLR3D,POLR2F,POLR2A,POLR1E,POLR3GL,POLR2H,TWISTNB,POLR3E |
| Purine metabolism | PPAT,NME1-NME2,AK4,GC2,ZNRD1,POLE2,POLA2,ADSL,AMPD3B,HPRT1 |
| Epstein-Barr virus infection | CD40,GSK3B,LYN,ENTPD3,ICAM1,TBPL2,RAN,PSMC3,FCER2,POLR2A |
| Pyrimidine metabolism | POLR1B,UPP1,POLR2L,UCK2A,DHODH,UCK2B,CTPS2,TK2,CTPS1A,NME2A |
| Cytosolic DNA-sensing pathway | IFNA13,IRF7,IL6,IKBKE,NFKBIAA,POLR3GLB,ZBP1,CCL4,POLR3A,CCL4L2 |
| Metabolic pathways | G6PDX,PLCH1,HYAL1,PGS1,ATP6V1C1,GSS,HYKK,PLCB1,AGK,ATP6V1A |
Protein Function
POLR1C has several biochemical functions, for example, DNA binding,DNA-directed RNA polymerase activity,contributes_to RNA polymerase I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR1C itself. We selected most functions POLR1C had, and list some proteins which have the same functions with POLR1C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein dimerization activity | STK3,MNTB,GATA3,NCOA2,ASCL3,TCF21,FIGLA,DAO,GARS,EPAS1B |
| DNA binding | RARAB,ORC1L,BEND5,APLP2,SOX3,TBX24,ZNF16,NR2F1B,POU3F3B,DNASE1L1 |
| contributes_to RNA polymerase I activity | POLR2F,POLR2E,POLR2L,POLR1D,TWISTNB,POLR2H,ZNRD1,POLR1E,POLR2EB,POLR2K |
| contributes_to RNA polymerase III activity | POLR2E,POLR3F,POLR3E,POLR2L,POLR2F,POLR1D,POLR3GL,POLR3H,POLR3K,POLR3GLA |
| DNA-directed RNA polymerase activity | POLR3G,CRCP,PRIM2,CD3EAP,MED20,POLR2A,POLR2D,POLR3A,POLR2M,POLR2EB |
| protein binding | PPP1R3C,PTRF,ANKRD49,CTNNA3,MYD88,GCC2,SKA1,IGF2,ANGPT2,CD276 |
Interacting Protein
POLR1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR1C here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR1C.
NME1;POLR1D;POLR2J;TNFAIP1
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References
- Schaefer, E; Collet, C; et al. Autosomal recessive POLR1D mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome. GENETICS IN MEDICINE 16:720-724(2014).
- Achilleos, A; Bugarinovic, G; et al. Polr1c and Polr1d knock-out mice as new genetic models for Treacher Collins Syndrome. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:1875-1875(2014).
