POLR1B
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Official Full Name
polymerase (RNA) I polypeptide B, 128kDa -
Overview
Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production;of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides,;depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in;yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 (PubMed 8921381)). -
Synonyms
POLR1B;polymerase (RNA) I polypeptide B, 128kDa;DNA-directed RNA polymerase I subunit RPA2;FLJ10816;FLJ21921;RPA2;Rpo1 2;A127;DNA directed RNA polymerase I 135kDa polypeptide;DNA directed RNA polymerase I;DNA directed RNA polymerase I subunit RPA2;MGC131780;OTTHUMP00000161989;OTTHUMP00000203643;OTTHUMP00000203645;POLR 1B;Polymerase (RNA) I polypeptide B 128kDa;Polymerase (RNA) I polypeptide B;RNA polymerase I polypeptide B;RNA polymerase I subunit 2;RPA 135;RPA116;RPA135;DNA-directed RNA polymerase I 135kDa polypeptide;DNA-directed RNA polymerase I 135 kDa polypeptide;Rpo1-2
Recombinant Proteins
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- Human
- Mammalian Cell
- HEK293
- His
- Non
- His&Fc&Avi
Involved Pathway
POLR1B involved in several pathways and played different roles in them. We selected most pathways POLR1B participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyrimidine metabolism | ITPA,POLR2I,UPRT,TK1,TYMP,NT5C1B,NME2B.2,NT5C2B,POLR2A,POLR1E |
| RNA polymerase | POLR2J,POLR1E,POLR1A,POLR2J2,POLR3B,POLR2B,POLR2F,POLR2J3,POLR2G,ZNRD1 |
| Metabolic pathways | POC1BL,ACER1,ABP1,ADA,RDH10,NT5C3A,PCK1,SARDH,GCNT4,ARG2 |
| Purine metabolism | PNP5B,ADCY2B,ADCY1B,ENTPD2,NTPCR,GUK1,ADA,ADSSL1,PDE8A,ENTPD3 |
Protein Function
POLR1B has several biochemical functions, for example, copper ion binding,protein binding,protein-lysine 6-oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR1B itself. We selected most functions POLR1B had, and list some proteins which have the same functions with POLR1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| scavenger receptor activity | TMPRSS4B,CFI,LOXL2A,LOXL2,SCARA3,PRG4,GM106,ACKR4,VTNB,LGALS3BPB |
| copper ion binding | ATOX1,SERPINB1A,S100A5,ABP1,APOA4,LOXL3B,CCS,MOXD2,HEPHL1,PRNPA |
| protein binding | MOB1A,EIF4EBP2,CNTNAP4,LIMA1,TMEM106B,FIBCD1,TRAF3IP3,DCTN5,NDEL1,KRT86 |
| protein-lysine 6-oxidase activity | LOXL3,LOX,LOXL2A,ABHD1,LOXL2B,LOXL2,LOXL4 |
Interacting Protein
POLR1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR1B here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR1B.
POLR1A;HDAC6;NCK1;PIK3R1;USP11;GRB2;NFKBIB;TAF1D;ZNF207;CCND1;AKT2;RPL37;GIT2;LDB1;MED20;ERBB2;ARRB2
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