POLG2
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Official Full Name
polymerase (DNA directed), gamma 2, accessory subunit -
Overview
DNA polymerasebeta is a distributive polymerase involved in base excision repair which repairs damaged DNA by excising modified bases (oxidized methylated deaminated etc.). It has single-strand DNA binding and deoxyribose phosphodiesterase activities on the N-terminal side and nucleotidyltransferase activity on the C-terminal side. The enzyme is constitutively expressed in growing cells but the level of expression is further increased by treatment with alkylating reagents such as MNNG and MMS. -
Synonyms
POLG2;polymerase (DNA directed), gamma 2, accessory subunit;DNA polymerase subunit gamma-2, mitochondrial
Recombinant Proteins
- Human
- Mouse
- HEK293
- E.coli
- Mammalian cells
- HEK293T
- Non
- His&SUMO
- His
- His&Fc&Avi
- Flag
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POLG2-3047HCL | Recombinant Human POLG2 293 Cell Lysate | HEK293 | Human | Non |
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| POLG2-1147H | Recombinant Human POLG2 Protein (1-485 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 1-485 aa |
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| POLG2-117H | Recombinant Human POLG2 protein, His-tagged | E.coli | Human | His | 1-335 aa |
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| POLG2-1729H | Recombinant Human POLG2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| POLG2-1729H-B | Recombinant Human POLG2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| POLG2-293HFL | Recombinant Full Length Human POLG2 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| Polg2-4988M | Recombinant Mouse Polg2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
POLG2 involved in several pathways and played different roles in them. We selected most pathways POLG2 participated on our site, such as Metabolic pathways,Mitochondrial biogenesis,Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial biogenesis | POLRMT,MTERF,TFB2M,TFB1M,GABPB1,PPRC1,C10orf2,ESRRA,GABPA,PPARGC1B |
| Organelle biogenesis and maintenance | BBS5,TTC30B,TCTN3,PPRC1,IFT172,UNC119B,NPHP1,IFT46,MKKS,MRPL42 |
| Metabolic pathways | REV3L,NDUFS1,UQCRB,PET112L,EXTL3,ITPK1A,ALDH3B2,ALG6,glpK,HADH |
| Transcriptional activation of mitochondrial biogenesis | GABPB1,PPRC1,MTERF,TFB1M,C10orf2,GABPA,POLRMT |
Protein Function
POLG2 has several biochemical functions, for example, DNA binding,DNA-directed DNA polymerase activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLG2 itself. We selected most functions POLG2 had, and list some proteins which have the same functions with POLG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | ALDOB,VWA2,NEFL,MTSS1,DAPK2,CHAF1A,SHARPIN,MRFAP1L1,ACY3,PHYKPL |
| protein binding | VEGFAB,THRAA,RHOH,HINFP,FHL1,POLR1D,UNC119B,TNNI3K,PLAT,PPP1R12A |
| DNA binding | HOXA4,XBP1,TLX3B,ZNF350,NR1I3,INO80,ZFP639,SPO11,HIST1H3D,HOXD3A |
| DNA-directed DNA polymerase activity | POLG,POLD3,POLE4,POLN,POLI,POLK,MYBBP1A,POLB,POLD4,POLL |
Interacting Protein
POLG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLG2.
POLG;ssdna_dn
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References
- Lee, SK; Zhao, MH; et al. Polymerase subunit gamma 2 affects porcine oocyte maturation and subsequent embryonic development. THERIOGENOLOGY 83:121-130(2015).
- Woodbridge, P; Liang, C; et al. POLG mutations in Australian patients with mitochondrial disease. INTERNAL MEDICINE JOURNAL 43:150-156(2013).
