POLE2
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Official Full Name
polymerase (DNA directed), epsilon 2 (p59 subunit) -
Overview
DNA polymerase epsilon subunit 2?is an?enzyme?that in humans is encoded by the?POLE2?gene. -
Synonyms
POLE2;polymerase (DNA directed), epsilon 2 (p59 subunit);DNA polymerase epsilon subunit 2;DPE2;DNA polymerase II subunit 2;DNA polymerase epsilon subunit B
Recombinant Proteins
- Mouse
- Chicken
- Zebrafish
- Human
- Mammalian Cells
- HEK293
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POLE2-13075M | Recombinant Mouse POLE2 Protein | Mammalian Cells | Mouse | His |
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| POLE2-1632C | Recombinant Chicken POLE2 | Mammalian Cells | Chicken | His |
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| POLE2-9520Z | Recombinant Zebrafish POLE2 | Mammalian Cells | Zebrafish | His |
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| POLE2-2454H | Recombinant Human POLE2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| POLE2-2637H | Recombinant Human POLE2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| POLE2-6907M | Recombinant Mouse POLE2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| POLE2-6907M-B | Recombinant Mouse POLE2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
POLE2 involved in several pathways and played different roles in them. We selected most pathways POLE2 participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Replication | FEN1,MCM5,rnhA,MCM4,PCNA,POLE3,RFC2,POLA1,RFC5,CDT1 |
| Pyrimidine metabolism | CAD,POLR2I,NME2A,RRM1,NME2B.2,POLR1A,POLD4,DUT,PRIM2,NT5M |
| Nucleotide Excision Repair | ERCC3,RAD23AB,POLD2,COPS2,YY1A,NFRKB,RBX1,ERCC1,POLE,COPS6 |
| Base excision repair | LIG1,MBD4,POLD1,PARP1,LIG3,POLE4,xthA,MUTYH,POLD4,POLB |
| Metabolic pathways | ALOX5A,CYP3A7,MAN1A1,CNDP2,ASAH1A,CYP17A1,PRIM2,PRPS1L1,Ckmm,AGXT2L1 |
| Purine metabolism | POLR3C,NUDT2,ADAL,POLR3D,PRPS1B,AK9,PKMA,ALLC,POLR2EB,PDE4D |
| HTLV-I infection | PIK3CD,HLA-DRA,LCK,PDGFRA,MYB,MAP3K1,IL1R1,PIK3R2,NFATC4,CCND1 |
Protein Function
POLE2 has several biochemical functions, for example, DNA binding,contributes_to DNA-directed DNA polymerase activity,nucleotidyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLE2 itself. We selected most functions POLE2 had, and list some proteins which have the same functions with POLE2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotidyltransferase activity | TAMM41,GMPPA,UAP1L1,PAPSS2,PAPSS1,TERT,OASL2,POLR2B,REV3L,GDPGP1 |
| transferase activity | ZDHHC18,HS3ST3B1A,GXYLT2,MAPKAPK2A,PTDSS1,PPM1E,TAOK3,DYRK1AA,UGT5B1,GKUP |
| DNA binding | VDR,ZNF436,SMAD9,HOXA5A,ZNF292A,VEZF1,POLL,TCEANC,RX1,BRIP1 |
Interacting Protein
POLE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLE2.
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References
- Chao, YH; Wu, KH; et al. Downregulated CXCL12 expression in mesenchymal stem cells associated with severe aplastic anemia in children. ANNALS OF HEMATOLOGY 94:13-22(2015).
- Liu, D; Zhang, XX; et al. Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer. INTERNATIONAL JOURNAL OF ONCOLOGY 45:1232-1240(2014).
