POLA2
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Official Full Name
polymerase (DNA directed), alpha 2 (70kD subunit) -
Overview
DNA polymerase alpha subunit B is an enzyme that in humans is encoded by the POLA2 gene. -
Synonyms
POLA2;polymerase (DNA directed), alpha 2 (70kD subunit);DNA polymerase alpha subunit B;FLJ21662;AI573378;DNA directed DNA polymerase alpha 2;DNA polymerase alpha 70 kDa subunit;DNA polymerase alpha subunit II;DNA polymerase subunit alpha B;DNA polymerase subunit II;FLJ37250;Polymerase (DNA directed), alpha (70kD);OTTHUMP00000231593;polymerase (DNA-directed), alpha (70kD)
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POLA2-1826H | Recombinant Human POLA2, GST-tagged | E.coli | Human | GST | 17-275aa | |
| POLA2-3502R | Recombinant Rhesus monkey POLA2 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| POLA2-9984Z | Recombinant Zebrafish POLA2 | Mammalian Cells | Zebrafish | His |
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| POLA2-3054HCL | Recombinant Human POLA2 293 Cell Lysate | HEK293 | Human | Non |
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| POLA2-3320R | Recombinant Rhesus Macaque POLA2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| POLA2-3320R-B | Recombinant Rhesus Macaque POLA2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
POLA2 involved in several pathways and played different roles in them. We selected most pathways POLA2 participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Replication | MCM2,GINS2,GINS3,RPA2,DBF4,MCM3L,MCM5,PRIM2,POLD1,POLD4 |
| Purine metabolism | ADCY2B,PDE10A,AK5,POLR3D,APRT,NT5C2,AK2,ENTPD1,PDE1C,POLE2 |
| Pyrimidine metabolism | udp,TYMP,DCK,PRIM1,TK1,POLA1,DPYS,POLE4,POLD2,DPYDB |
| Metabolic pathways | MSMO1,UGT1A2,HPSE2,OXSM,PDXP,CYP2C37,PKMB,MTMR4,SAT1A.2,ACLY |
Protein Function
POLA2 has several biochemical functions, for example, DNA binding,DNA-directed DNA polymerase activity,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by POLA2 itself. We selected most functions POLA2 had, and list some proteins which have the same functions with POLA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | IRF2A,ZFP41,ZNF726,SP6,ZNF573,RXRA,ZKSCAN3,TIGD2,ASXL1,TFAP2B |
| DNA-directed DNA polymerase activity | POLG,POLE4,PAPD7,CHRAC1,POLK,POLD1,POLD2,POLD4,DNTT,POLE |
| molecular_function | SPON2B,AGPHD1,IGSF10,ZNF614,CPNE9,AMMECR1,SPAG8,NACAD,LYRM7,CRYGM2D1 |
| protein heterodimerization activity | LIFR,POLA1,SCGB2A1,PANX2,NFYC,JAM3,HIST1H2BM,H2AFVA,HIST3H2A,H2-AB1 |
Interacting Protein
POLA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLA2.
CHM;CPE;IGFBP3;FGFR3;NR4A1;LRPAP1;ATP5C1;NHP2L1;ITGB3BP;DHX34;SETDB1;EZH2;RNPC4;DCP2;FAM219A;ULK2;STK40;PRPF38A;FRZB;C8orf30A
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References
- Lin, JJ; Wang, XD; et al. alpha-1,3-N-acetylgalactose aminotransferase gene 539G > C mutation leads to the A(2)B isoform. GENETICS AND MOLECULAR RESEARCH 13:2987-2993(2014).
- Jeng, JE; Tsai, HR; et al. Independent and Additive Interactive Effects Among Tumor Necrosis Factor-alpha Polymorphisms, Substance Use Habits, and Chronic Hepatitis B and Hepatitis C Virus Infection on Risk for Hepatocellular Carcinoma. MEDICINE 88:349-357(2009).
