PNPLA1
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Official Full Name
patatin-like phospholipase domain containing 1 -
Overview
The protein encoded by this gene belongs to the patatin-like phospholipase (PNPLA) family, which is characterized by;the presence of a highly conserved patatin domain. PNPLA family members have diverse lipolytic and acyltransferase;activities, and are key elements in lipid metabolism. While other members of this family have been well characterized,;the function of this gene remained an enigma. However, recent studies show that this gene is expressed in the skin;epidermal keratinocytes, and has a role in glycerophospholipid metabolism in the cutaneous barrier. Consistent with;these observations, mutations in this gene are associated with ichthyosis in human (autosomal recessive congenital;ichthyoses, ARCI) and dog. Alternatively spliced transcript variants encoding different isoforms have been found for;this gene. -
Synonyms
PNPLA1;patatin-like phospholipase domain containing 1;patatin-like phospholipase domain-containing protein 1;dJ50J22.1;FLJ38755;MGC119320;MGC119321;MGC119319;OTTHUMP00000016289;OTTMUSP00000028874;Patatin like phospholipase domain containing protein 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PNPLA1-3070HCL | Recombinant Human PNPLA1 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
PNPLA1 involved in several pathways and played different roles in them. We selected most pathways PNPLA1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPLA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PNPLA1 has several biochemical functions, for example, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPLA1 itself. We selected most functions PNPLA1 had, and list some proteins which have the same functions with PNPLA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrolase activity | G6PC3,DNASE2A,DESI1,FHIT,ATP11A,Gzmd,PLBD1,PAPL,CTDSPL2A,PTPRDB |
Interacting Protein
PNPLA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPLA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPLA1.
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References
- Huang, CF; Dai, CY; et al. Association of diabetes and PNPLA3 genetic variants with disease severity of patients with chronic hepatitis C virus infection. JOURNAL OF HEPATOLOGY 62:512-518(2015).
- Zhou, Y; Llaurado, G; et al. Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2. JOURNAL OF HEPATOLOGY 62:657-663(2015).
