PMS2
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Official Full Name
PMS2 postmeiotic segregation increased 2 -
Overview
Microsatellite instability (MSI) is characterized by genome-wide alterations in short, repetitive DNA sequences. It is caused by defects in the nucleotide mismatch repair (MMR) system. Biologically, defective MMR results in a general increase in the mutat -
Synonyms
PMS2;PMS2 postmeiotic segregation increased 2 (S. cerevisiae);PMSL2, postmeiotic segregation increased (S. cerevisiae) 2;mismatch repair endonuclease PMS2;H_DJ0042M02.9;HNPCC4;PMS1 protein homolog 2;DNA mismatch repair protein PMS2;PMSL2;PMS2CL
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PMS2-1383HCL | Recombinant Human PMS2 cell lysate | Human | Non |
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| PMS2-1017H | Recombinant Human PMS2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| PMS2-1490HFL | Recombinant Full Length Human PMS2 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| PMS2-1720H | Recombinant Human PMS2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| PMS2-1720H-B | Recombinant Human PMS2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| PMS2-197H | Recombinant Human PMS2 protein, His-tagged | E.coli | Human | His | 513-862 aa |
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Involved Pathway
PMS2 involved in several pathways and played different roles in them. We selected most pathways PMS2 participated on our site, such as Mismatch repair,Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PMS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | POLK,UBE2T,C19orf40,HER9,POLN,HER6,RPA4,ERCC1,TOP3B,RAD51 |
| Mismatch repair | MSH6,RFC1,MLH3,RPA2,PCNA,MLH1,POLD1,SSBP1,MSH2,RFC5 |
Protein Function
PMS2 has several biochemical functions, for example, ATP binding,ATPase activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PMS2 itself. We selected most functions PMS2 had, and list some proteins which have the same functions with PMS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZMAT4,ZNF692,ZNF285A,ZNF697,RUNX2A,ARID3B,NR0B2A,NKX6.2,RABGAP1,SATB1A |
| protein binding | FBXO3,CSE1L,DNER,CD6,NEDD4,GCH1,RBBP4,KRT7,CADM1,BPTF |
| ATP binding | LYN,NLRP7,RUNX2B,UBE2D4,EPHB1,SLK,MCCC1,GMPS,CARKD,MSH4 |
| contributes_to MutSalpha complex binding | MLH1 |
| ATPase activity | DDX3X,ABCA4A,NSF,CLPB,DNAHC8,ABCF1,ABCA5,ABCE1,PEX6,NSFA |
| contributes_to single-stranded DNA binding | MSH3,IGHM,POLR2D,MLH1,MSH2,IGJ |
| endonuclease activity | ENDOU2,ZC3H12A,PPP1R8,RNASEKB,RAG1,APEX1,ANG4,EAR5,EAR14,G3BP1 |
Interacting Protein
PMS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PMS2.
MLH1;BRIP1;FSCN1;ZNF189;RASA1;XPA;AKT1;PPP2CB
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References
- Roth, RM; Hampel, H; et al. A Modified Lynch Syndrome Screening Algorithm in Colon Cancer BRAF Immunohistochemistry Is Efficacious and Cost Beneficial. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 143:336-343(2015).
- Muro, Y; Nakashima, R; et al. Autoantibodies to DNA Mismatch Repair Enzymes in Polymyositis/Dermatomyositis and Other Autoimmune Diseases: A Possible Marker of Favorable Prognosis. ARTHRITIS & RHEUMATOLOGY 66:3457-3462(2014).
