PMS1
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Official Full Name
PMS1 postmeiotic segregation increased 1 -
Overview
This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. -
Synonyms
PMS1;PMS1 postmeiotic segregation increased 1 (S. cerevisiae);PMSL1, postmeiotic segregation increased (S. cerevisiae) 1;PMS1 protein homolog 1;mismatch repair gene PMSL1;human homolog of yeast mutL;DNA mismatch repair protein PMS1;rhabdomyosarcom
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PMS1-2843H | Recombinant Human PMS1 protein, His-tagged | E.coli | Human | His | 1 - 166 aa | |
| PMS1-3319H | Recombinant Human PMS1 protein, His-tagged | E.coli | Human | His | 340-616 aa | |
| PMS1-11466Z | Recombinant Zebrafish PMS1 | Mammalian Cell | Zebrafish | His |
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| PMS1-1646C | Recombinant Chicken PMS1 | Mammalian Cell | Chicken | His |
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| PMS1-3085HCL | Recombinant Human PMS1 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
PMS1 involved in several pathways and played different roles in them. We selected most pathways PMS1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PMS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PMS1 has several biochemical functions, for example, ATP binding,ATPase activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PMS1 itself. We selected most functions PMS1 had, and list some proteins which have the same functions with PMS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | NKX1.2LA,RAD51B,GATA1,EVX2,SSH1,POLR2F,HIST1H2B7,GTF2F2A,TCF25,NFE2L2A |
| ATP binding | MYLK4,CDK12,MARK2,WEE2,PSMC1,CSNK1G3,ATP13A,PRKCZ,CDKL4,DDX39AA |
| ATPase activity | KIF14,ABCC5,ABCC1,KIF21A,VPS4A,OLA1,KIF1B,ABCG3,HSP90AA1,ATAD2B |
| single-stranded DNA binding | MCM6,ERCC5,TTC6,CNBPA,NUP35,HNRNPK,ERCC1,SETMAR,ERCC4,PEO1 |
| mismatched DNA binding | TDG,MLH3,MSH6,MSH4,MLH1,MSH5 |
Interacting Protein
PMS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PMS1.
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References
- Galles, C; Gomez, RL; et al. PMS1 from Arabidopsis thaliana: optimization of protein overexpression in Escherichia coli. MOLECULAR BIOLOGY REPORTS 38:1063-1070(2011).
- Muro, Y; Nakashima, R; et al. Autoantibodies to DNA Mismatch Repair Enzymes in Polymyositis/Dermatomyositis and Other Autoimmune Diseases: A Possible Marker of Favorable Prognosis. ARTHRITIS & RHEUMATOLOGY 66:3457-3462(2014).
