PMCH
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Official Full Name
pro-melanin-concentrating hormone -
Overview
The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and;later from rat hypothalamus. In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona;incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic;distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions;directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other;putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in;many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH) (summary;by Nahon et al., 1992 (PubMed 1572663)). -
Synonyms
PMCH;pro-melanin-concentrating hormone;pro-MCH;MCH;melanin-concentrating hormone
Recombinant Proteins
- Human
- Chicken
- Rat
- Zebrafish
- HEK293
- Mammalian Cell
- E.coli
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PMCH-172H | Recombinant Human PMCH, His-tagged | HEK293 | Human | His | 22-165 a.a. |
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| PMCH-4155C | Recombinant Chicken PMCH | Mammalian Cell | Chicken | His |
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| PMCH-4540R | Recombinant Rat PMCH Protein | Mammalian Cell | Rat | His |
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| PMCH-646H | Recombinant Human PMCH Protein, His-tagged | E.coli | Human | His |
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| PMCH-8000Z | Recombinant Zebrafish PMCH | Mammalian Cell | Zebrafish | His |
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| PMCH-488HCL | Recombinant Human PMCH lysate | HEK293 | Human | Non |
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| PMCH-2149H | Recombinant Human PMCH Protein, His-tagged | E.coli | Human | His |
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| PMCH-4200R | Recombinant Rat PMCH Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PMCH-4200R-B | Recombinant Rat PMCH Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
PMCH involved in several pathways and played different roles in them. We selected most pathways PMCH participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events,G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PMCH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | RXFP2B,TAS2R16,OXGR1A.3,APPB,APLNR,OR52J3,CCL35.1,RASGRP2,QRFPR,ADRA2A |
| Signal Transduction | ARHGEF1A,NCKIPSD,BCO2A,TAGAPB,WWOX,NPS,DHRS9,GNA13B,KISS1,BOC |
| Peptide ligand-binding receptors | UTS2,PNOCB,GAL,QRFP,RXFP2,NPSR1,FPR-RS6,CXCL11.8,PENKA,CCL27 |
| G alpha (i) signalling events | TAS2R13,OPN1LW1,SOUL3,OPN1MW,CCR3,TAS2R16,CCR6,APPA,RGS10,NMU |
| Class A/1 (Rhodopsin-like receptors) | ADRA1B,GPR65,EDN2,ADORA1,SST,CCRL2,ADRA2B,ADRB2,OXGR1,OPN1LW1 |
| GPCR ligand binding | GAL,GPR4,HRH3,EDN2,RAMP2,CRHR1,LPAR2A,FPR-RS4,CD97,S1PR1 |
| Gastrin-CREB signalling pathway via PKC and MAPK | DGKQ,EDN2,TAC3,ABHD12,NPS,UTS2,TAE1,PROKR1,ABHD6B,LTB4R |
| G alpha (q) signalling events | EDN2,RASGRP2,TRPC7,MLN,NPSR1,FPR-RS4,EDNRB,KALRN,CYSLTR1,DGKA |
Protein Function
PMCH has several biochemical functions, for example, melanin-concentrating hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PMCH itself. We selected most functions PMCH had, and list some proteins which have the same functions with PMCH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| melanin-concentrating hormone activity | PMCHL |
Interacting Protein
PMCH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMCH here. Most of them are supplied by our site. Hope this information will be useful for your research of PMCH.
Resources
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References
- Walter, LJ; Gasch, CA; et al. Association of pro-melanin concentrating hormone genotype with beef carcass quality and yield. JOURNAL OF ANIMAL SCIENCE 92:325-331(2014).
- Tuziak, SM; Rise, ML; et al. An investigation of appetite-related peptide transcript expression in Atlantic cod (Gadus morhua) brain following a Camelina sativa meal-supplemented feeding trial. GENE 550:253-263(2014).
