PLK2
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Official Full Name
polo-like kinase 2 -
Overview
The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PLK2;polo-like kinase 2;polo like kinase 2 (Drosophila);serine/threonine-protein kinase PLK2;serum inducible kinase;SNK;PLK-2;serum-inducible kinase;serine/threonine-protein kinase SNK;hSNK;hPlk2
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Insect (sf21)
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
- His&Myc
Involved Pathway
PLK2 involved in several pathways and played different roles in them. We selected most pathways PLK2 participated on our site, such as FoxO signaling pathway,PLK2 and PLK4 events,Polo-like kinase signaling events in the cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | TGFBR1B,NLK,STK4,MAPK14B,CCNB1,HRASA,FOXO3B,HOMER1,PDPK1,KLF2B |
| Polo-like kinase signaling events in the cell cycle | PLK3 |
Protein Function
PLK2 has several biochemical functions, for example, ATP binding,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLK2 itself. We selected most functions PLK2 had, and list some proteins which have the same functions with PLK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MAPKAPK2,NME7,CKBA,DYRK1A,BCS1L,HYOU1,NLRP7,CHD2,KIF6,NEK12 |
| protein serine/threonine kinase activity | RAF1,MYO3A,MELK,ZNF143B,MAP2K5,DYRK3,PAK2A,RPS6KA5,TTK,AKT2L |
| protein complex binding | TXN2,GIT2,PRKACA,PPFIA2,MTHFR,HADHA,CCNE1,TAPBPL,CRHR1,NCK2 |
| protein binding | STYX,CTNNA1,SIRT7,BEX2,ZRSR2,SOX15,KRT7,SMCO4,BAAT,PNMA5 |
| signal transducer activity | TAS2R139,MIER1B,CSPG4,FPR-RS3,PTGER4A,OLFR493,CXXC5,TAAR11,MUL1A,GJA1 |
Interacting Protein
PLK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLK2.
CDC20B;CENPJ;Plk2;CASK;IKBKAP;MPP3;y1093;fhuB;DLGAP4;C1orf226;FXR1;ITPR1;FGD6;PCGF5;MFN1;RTN4IP1
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