PLEKHA3
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Official Full Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 -
Overview
Binds specifically to phosphatidylinositol-4-phosphate (PtdIns4P), but not to other phosphoinositides. -
Synonyms
PLEKHA3;pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3;pleckstrin homology domain-containing family A member 3;FAPP1;four phosphate adaptor protein 1;FAPP 1;FAPP-1;FLJ20067;PH domain-containing family A member 3;Phosphatidylinositol-four-phosphate adapter protein 1;Phosphoinositol 4 phosphate adaptor protein 1;Phosphoinositol 4-phosphate adapter protein 1;PKHA3_HUMAN;Pleckstrin homology domain containing family A (phosphoinositide binding specific) member 3;Pleckstrin homology domain containing family A member 3;PLEKHA 3;OTTHUMP00000205697;four-phosphate-adaptor protein 1;p
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PLEKHA3-1776H | Recombinant Human PLEKHA3, GST-tagged | E.coli | Human | GST | 1-300aa | |
| PLEKHA3-11423Z | Recombinant Zebrafish PLEKHA3 | Mammalian Cell | Zebrafish | His |
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| PLEKHA3-2910C | Recombinant Chicken PLEKHA3 | Mammalian Cell | Chicken | His |
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| PLEKHA3-3117HCL | Recombinant Human PLEKHA3 293 Cell Lysate | HEK293 | Human | Non |
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| PLEKHA3-4551H | Recombinant Human PLEKHA3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Plekha3-4926M | Recombinant Mouse Plekha3 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
PLEKHA3 involved in several pathways and played different roles in them. We selected most pathways PLEKHA3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PLEKHA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PLEKHA3 has several biochemical functions, for example, 1-phosphatidylinositol binding,phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLEKHA3 itself. We selected most functions PLEKHA3 had, and list some proteins which have the same functions with PLEKHA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-phosphatidylinositol binding | SCIN,PICALMA,FRMPD2,PICALM,ZFYVE9,PICALMB,ZFYVE1,WDFY3,CCDC167,EPB41 |
| phospholipid binding | F10,APOEA,BIN2,AMPH,PACSIN1,DGKA,ABCG1,SGIP1,PICALMB,SPTB |
Interacting Protein
PLEKHA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLEKHA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLEKHA3.
CSDE1;Csde1
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References
- Ooms, LM; Horan, KA; et al. The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease. BIOCHEMICAL JOURNAL 419:29-49(2009).
- Liu, JM; Fukuda, K; et al. Structural Basis of Phosphoinositide Binding to Kindlin-2 Protein Pleckstrin Homology Domain in Regulating Integrin Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 286:43334-43342(2011).
