PLCB2
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Official Full Name
phospholipase C, beta 2 -
Synonyms
PLCB2;phospholipase C, beta 2;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2;FLJ38135;PLC-beta-2;phospholipase C-beta-2;phosphoinositide phospholipase C-beta-2;1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- His
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
PLCB2 involved in several pathways and played different roles in them. We selected most pathways PLCB2 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLCB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutamatergic synapse | PLA2G4F,GLS,SHANK3,GRIA3,PLD2,PLD1,PRKCA,GNG4,GRIK4,Adcy4 |
| Adrenergic signaling in cardiomyocytes | PIK3R3,PPP1CAB,ATP1B3,RYR2,ADCY1B,MAPK11,ATP2B4,ATP1B3A,ADRa1A,PPP2R2C |
| Retrograde endocannabinoid signaling | GNGT1,GNGT2,GNG12,GRIA1,GABRQ,GNAI1,GABRD,GABRR3,GRIA4,GNG11 |
| Insulin secretion | GPR119,Adcy4,KCNN4,ITPR3,CREB3L3,KCNMB4,ATF4,PCLO,SLC2A1,SNAP25 |
| Renin secretion | PPP3CA,CLCA4,NPR1,CALM2,PLCB4,GUCY1A3,CLCA5,REN2,AQP1,PRKACB |
| Pancreatic secretion | ATP1B3,ATP1B1,TPCN2,KCNMA1,PLA2G12A,ATP1B2,ATP2A1,SCTR,PLA2G5,ATP1A3 |
| Gap junction | Adcy4,TUBA1L2,PLCB1,ITPR3,SOS1,Pdgfa&Pdgfb,DRD2A,MAP2K2A,GNA15.1,CDK1 |
| GnRH signaling pathway | GNAQ,PTK2BB,CGNRH-R,GNAS,PRKACBA,CDC42L2,GNRHR,CACNA1D,GNRHR4,PRKACG |
| Thyroid hormone synthesis | DUOXA2,CREB3L1,GPX5,TSHB,ATP1B3,Adcy4,PLCB3,ASGR1,ITPR3,CREB3L3 |
Protein Function
PLCB2 has several biochemical functions, for example, calcium ion binding,phosphatidylinositol phospholipase C activity,phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLCB2 itself. We selected most functions PLCB2 had, and list some proteins which have the same functions with PLCB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol phospholipase C activity | CHRM3,PLCZ1,PLCD3,PLCD1,CHRM5,PLCE1,CCR5,PLCL1,PLCD4,PLCD3A |
| phospholipase C activity | PLCB4,PDIA3,PLCL1,PLCH2,ADORA1,PLCE1,PLCG1,PLCG2,PLCB3 |
| signal transducer activity | CXCR7B,OLFR154,STMN1,MGAA,OLFR476,NPFFR1L3,GNGT2,TRIM38,PLCZ1,OPRD1A |
| calcium ion binding | CAPN2A,SYT1,PCDH10,PROCA,NUCB2A,BMP1,DSG1,PADI2,F7,CAPN3A |
Interacting Protein
PLCB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLCB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLCB2.
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PLCB2 Related Signal Pathway
Resources
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References
- Chae, JJ; Park, YH; et al. Connecting Two Pathways Through Ca2+ Signaling: NLRP3 Inflammasome Activation Induced by a Hypermorphic PLCG2 Mutation. ARTHRITIS & RHEUMATOLOGY 67:563-567(2015).
- Maranhao, RC; Leite, ACA; et al. Development of Anti-Atherosclerosis Therapy Based on the Inflammatory and Proliferative Aspects of the Disease. CURRENT PHARMACEUTICAL DESIGN 21:1196-1204(2015).
