PKD1L2
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Official Full Name
polycystic kidney disease 1-like 2 -
Overview
This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PKD1L2;polycystic kidney disease 1-like 2;polycystic kidney disease protein 1-like 2;KIAA1879;PC1 like 2 protein;PKD1L 2;Polycystic kidney disease 1 like protein 2;Polycystin 1 like 2;polycystin-1L2;OTTHUMP00000231957;OTTHUMP00000231959;OTTHUMP00000231961;PC1-like 2 protein;PC1L2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PKD1L2-1738H | Recombinant Human PKD1L2, GST-tagged | E.coli | Human | GST | 686-992aa | |
| PKD1L2-1362HCL | Recombinant Human PKD1L2 cell lysate | Human | Non |
|
Involved Pathway
PKD1L2 involved in several pathways and played different roles in them. We selected most pathways PKD1L2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PKD1L2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PKD1L2 has several biochemical functions, for example, calcium ion binding,carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKD1L2 itself. We selected most functions PKD1L2 had, and list some proteins which have the same functions with PKD1L2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CALM,CAPN3,CALU,FSTL1A,SCIN,PCDH1G30,NUCB2A,GUCA1B,CIB3,MYL12.2 |
| carbohydrate binding | HBL4,CHI3L2,LGALS9C,KLRB1B,CLEC4E,SIGLEC14,CLEC1B,Cd24a,APCS,MAG |
Interacting Protein
PKD1L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKD1L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKD1L2.
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References
- Vural, M; Olgun, A; et al. AMINO ACID SIMILARITY, BETWEEN STATIN BINDING SITE OF HMG CoA REDUCTASE AND TASTE PERCEPTION-RELATED PROTEINS: A POSSIBLE MECHANISM FOR STATIN-INDUCED TASTE DISORDERS. NOBEL MEDICUS 8:105-107(2012).
- Fujimoto, C; Ishimaru, Y; et al. The single pore residue Asp(523) in PKD2L1 determines Ca2+ permeation of the PKD1L3/PKD2L1 complex. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 404:946-951(2011).
