PKD1
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Official Full Name
polycystic kidney disease 1 (autosomal dominant) -
Overview
This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. -
Synonyms
PKD1;polycystic kidney disease 1 (autosomal dominant);polycystin-1;PBP;Pc 1;polycystin 1;transient receptor potential cation channel;subfamily P;member 1;TRPP1;Autosomal dominant polycystic kidney disease 1 protein;Autosomal dominant polycystic kidney disease protein 1;OTTHUMP00000208669;OTTHUMP00000208670;Pc-1;PKD;PKD1_HUMAN;Polycystic Kidney Disease 1;polycystic kidney disease-associated protein;Polycystin 1 Precursor;transient receptor potential cation channel, subfamily P, member 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PKD1-12857M | Recombinant Mouse PKD1 Protein | Mammalian Cell | Mouse | His |
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| PKD1-4469H | Recombinant Human PKD1 protein, His&His-tagged | E.coli | Human | His | 25-636aa |
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| PKD1-4470H | Recombinant Human PKD1 protein, His-tagged | E.coli | Human | His | 25-636aa |
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| PKD1-6777M | Recombinant Mouse PKD1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PKD1-6777M-B | Recombinant Mouse PKD1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PKD1 involved in several pathways and played different roles in them. We selected most pathways PKD1 participated on our site, such as Assembly of the primary cilium,Cargo trafficking to the periciliary membrane,Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of the primary cilium | IFT43,CNGA2,MARK4,ARF4,NPHP3,DYNLRB2,RABL5,PLK4,IFT27,NPHP4 |
| VxPx cargo-targeting to cilium | RAB3IP,CNGA2,ARF4,PKD2,ARF4A,CNGA5 |
| XPodNet - protein-protein interactions in the podocyte expanded by STRING | FAM65A,GIMAP3,OASL2,KCP,RAVER1,SNTB1,FRAS1,CMIP,CARF,ZFP423 |
| Organelle biogenesis and maintenance | MRPL39,CC2D2A,BBS9,GFM2,BBS10,PROL1,RABL5,IQCB1,MRRF,DYNLL2A |
| Cargo trafficking to the periciliary membrane | CYS1,CNGA2,SETD6,MKKS,CCT2,CCT4,BBS1,EXOC1,ARF4A,ARL13B |
Protein Function
PKD1 has several biochemical functions, for example, calcium channel activity,carbohydrate binding,cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PKD1 itself. We selected most functions PKD1 had, and list some proteins which have the same functions with PKD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ion channel binding | RANGRF,KCNAB1,FGF12,ABCC9,PDE4B,CALM3,DLG1,SNTA1,KCND3,ACTN4 |
| calcium channel activity | PSEN1,TRPC7A,TRPM2,CACNG7A,CACNG1A,TRPM1,TRPV2,CUL5,PKD2L1,PANX1 |
| protein kinase binding | AURKA,JTB,STXBP1,PTPN23,PDCD10,MVP,NPR1,CRY1,SKI,EEF1A2 |
| cation channel activity | TRPM1A,PKD2L1,ASIC1A,TRPM1,FAM38A,TRPV4,ASIC4A,GAR1,TRPV2,CALHM3 |
| protein domain specific binding | NR0B1,CALM2,CACNB2,DICER1,ARRB2,RQCD1,XPO1,OCLN,THRA,E2F4 |
| carbohydrate binding | SIGLEC11,CD34,LGALS3,KLRB1B,CLEC4D,LGALS4,SI,GALNT3,MAN2C1,NOMO2 |
| protein binding | S100P,PSMC4,STRA13,LEMD3,PIP,EFCAB11,TNPO2,MYLK,BLOC1S6,AKAP7 |
Interacting Protein
PKD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKD1.
SF1;Pkd2;Id2;ACTB;PDK2;Actb;CTTN
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References
- Lian, PW; Li, A; et al. Loss of Polycystin-1 Inhibits Bicc1 Expression during Mouse Development. PLOS ONE 9:-(2014).
- Vijayakumar, S; Dang, S; et al. Aberrant expression of laminin-332 promotes cell proliferation and cyst growth in ARPKD. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 306:F640-F654(2014).
