PJA1
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Official Full Name
praja ring finger 1 -
Overview
This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked mental retardation disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. -
Synonyms
PJA1;praja ring finger 1;praja 1;E3 ubiquitin-protein ligase Praja-1;FLJ11830;RNF70;E3 ubiquitin-protein ligase Praja 1;PJA1_HUMAN;Praja1;RING finger protein 70;RNF 70;RP23-414J22.4;OTTHUMP00000023457;OTTHUMP00000023458;OTTHUMP00000158771
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PJA1-114H |
Active Recombinant Human PJA1, SUMO-tagged
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E.coli | Human | SUMO |
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| PJA1-12855M | Recombinant Mouse PJA1 Protein | Mammalian Cell | Mouse | His |
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| PJA1-3160HCL | Recombinant Human PJA1 293 Cell Lysate | HEK293 | Human | Non |
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| PJA1-6775M | Recombinant Mouse PJA1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PJA1-6775M-B | Recombinant Mouse PJA1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PJA1 involved in several pathways and played different roles in them. We selected most pathways PJA1 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PJA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing: Ubiquitination & | FBXO44,LRR1,UBE2F,WSB1,VPRBP,UBE2V1,RNF4,RBCK1,ASB14,SPSB2 |
| presentation | RNF25,STUB1,UBE2F,FBXO3,UBE2V1,ASB8,RNF220,VPRBP,ASB17,GAN |
| Class I MHC mediated antigen processing & | UBR2,TRIM11,TRIM50,LRRC41,SH3RF1,ARIH2,CD207,RNF34,UBE2F,RNF138 |
| Immune System | SEC24A,HLA-DQB2,KIF2C,STUB1,ART1,NCR3LG1,XAF1,TANK,MKRN1,DYNC1I1 |
| Adaptive Immune System | AKR1C1,DYNLL2,CD300LH,KIF18A,CD200R4,DCTN3,CLTA,FBXO17,ERAP1,KIF15 |
| Proteasome degradation | DTX3L,ASB18,FBXO27,GAN,ASB13,ASB4,TRAF7,TRIM50,HUWE1,TPP2 |
Protein Function
PJA1 has several biochemical functions, for example, ligase activity,protein binding,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PJA1 itself. We selected most functions PJA1 had, and list some proteins which have the same functions with PJA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | TNFAIP3,RNF169,TRIM23,RTCB,MUL1A,RNF111,UBE2KA,TRIM13,HERC4,COP1 |
| zinc ion binding | ADAMTS8,ESR2A,ZRANB1B,BTR06,RBCK1,MEP1A.1,BRPF3,TRIM35-30,TK1,QPCTLA |
| ubiquitin protein ligase activity | TRAIP,RAG2,UBE2J2,UBE2U,SYVN1,UBR5,PDZRN3,SIAH2L,AMFR,MSL2B |
| protein binding | EDARADD,NGLY1,FBXO27,RAB18,SPI1B,HMGB4,PADI4,TAGLN2,CMTM2A,TMEM93 |
Interacting Protein
PJA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PJA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PJA1.
MAGED1;NDNL2;SMAD3;GSR;HNRNPL;ATP5C1;KIF22;UBE2U;ZNF440;ASCC2;RIBC2;Irak1
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References
- Farajzadeh, L; Hornshoj, H; et al. Pairwise comparisons of ten porcine tissues identify differential transcriptional regulation at the gene, isoform, promoter and transcription start site level. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 438:346-352(2013).
- Petit, F; Andrieux, J; et al. Xq12q13.1 microduplication encompassing the EFNB1 gene in a boy with congenital diaphragmatic hernia. EUROPEAN JOURNAL OF MEDICAL GENETICS 54:E525-E527(2011).
